Amfr - autocrine motility factor receptor Gene

Also Known as gp78

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23802

Summary

Predicted to enable several functions, including BAT3 complex binding activity; chaperone binding activity; and Ubiquitin-Specific Protease binding activity. Involved in negative regulation of canonical Wnt signaling pathway and regulation of SREBP signaling pathway. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and perinuclear region of cytoplasm. Predicted to be integral component of endoplasmic reticulum membrane and integral component of plasma membrane. Predicted to be part of Derlin-1 retrotranslocation complex and ubiquitin Ligase complex. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; integumental system; liver; and retina nuclear layer. Orthologous to human AMFR (autocrine motility factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Amfr Products (16)

mRNA Protein Name
NM_001414270.1 NP_001401199.1 E3 ubiquitin-protein ligase AMFR isoform 2
NM_001414271.1 NP_001401200.1 E3 ubiquitin-protein ligase AMFR isoform 3
NM_001414272.1 NP_001401201.1 E3 ubiquitin-protein ligase AMFR isoform 4
NM_001414273.1 NP_001401202.1 E3 ubiquitin-protein ligase AMFR isoform 5
NM_001414274.1 NP_001401203.1 E3 ubiquitin-protein ligase AMFR isoform 6
NM_001414275.1 NP_001401204.1 E3 ubiquitin-protein ligase AMFR isoform 6
NM_001414276.1 NP_001401205.1 E3 ubiquitin-protein ligase AMFR isoform 8
NM_011787.3 NP_035917.2 E3 ubiquitin-protein ligase AMFR isoform 1
NM_001414270.1 NP_001401199.1 E3 ubiquitin-protein ligase AMFR isoform 2
NM_001414271.1 NP_001401200.1 E3 ubiquitin-protein ligase AMFR isoform 3
NM_001414272.1 NP_001401201.1 E3 ubiquitin-protein ligase AMFR isoform 4
NM_001414273.1 NP_001401202.1 E3 ubiquitin-protein ligase AMFR isoform 5
NM_001414274.1 NP_001401203.1 E3 ubiquitin-protein ligase AMFR isoform 6
NM_001414275.1 NP_001401204.1 E3 ubiquitin-protein ligase AMFR isoform 6
NM_001414276.1 NP_001401205.1 E3 ubiquitin-protein ligase AMFR isoform 8
NM_011787.3 NP_035917.2 E3 ubiquitin-protein ligase AMFR isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16709668 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
31073040 MGI
involved in regulation of SREBP signaling pathway IMP
IMP: Inferred from mutant phenotype
22863805 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase AMFR

  • AMF receptor

  • RING-type E3 ubiquitin transferase AMFR

Amfr Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Amfr Q9R049 Ngly1 Mus musculus Q9JI78
Y2H
16709668
Intra
Amfr Q9R049 Ngly1 Mus musculus Q9JI78
Pull Down
16709668
Intra
Amfr Q9R049 Ngly1 Mus musculus Q9JI78
Anti Tag CoIP
16709668
Intra
Amfr Q9R049 Vcp Mus musculus Q01853
Pull Down
16709668
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00652 AMFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20690 Amfr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27201 Amfr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Amfr NCBI NCBI:267