A4galt - alpha 1,4-galactosyltransferase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 239559

Summary

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the Bacterial verotoxins receptor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]

A4galt Products (3)

mRNA Protein Name
NM_001004150.4 NP_001004150.2 lactosylceramide 4-alpha-galactosyltransferase
NM_001170954.2 NP_001164425.2 lactosylceramide 4-alpha-galactosyltransferase
NM_001370647.1 NP_001357576.1 lactosylceramide 4-alpha-galactosyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lactosylceramide 4-alpha-galactosyltransferase activity IDA
IDA: Inferred from direct assay
16476743 MGI
enables lactosylceramide 4-alpha-galactosyltransferase activity IMP
IMP: Inferred from mutant phenotype
16476743 MGI
enables toxic substance binding IMP
IMP: Inferred from mutant phenotype
16476743 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within globoside biosynthetic process IDA
IDA: Inferred from direct assay
16476743 MGI
acts upstream of or within globoside biosynthetic process IMP
IMP: Inferred from mutant phenotype
16476743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lactosylceramide 4-alpha-galactosyltransferase

  • Gb3 synthase

  • Gb3/CD77 synthase

  • UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase

  • alpha-1,4-N-acetylglucosaminyltransferase

  • alpha4Gal-T1

  • globotriaosylceramide synthase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70047 alpha-1,4-Galactosyltransferase (LgtC) / Unkown
HY-156208 C2 Adamantanyl galactosylceramide (d18:1/2:0) / Unkown
HY-RS00013 A4GALT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149125 Globotriaosylceramide (porcine RBC) Inhibitor / Unkown
HY-RS18003 A4galt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24475 A4galt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens A4galt NCBI NCBI:53947