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Tnfsf18 - tumor necrosis factor (ligand) superfamily, member 18 Gene

Also Known as Gitrl; Tnlg2a

Species: Mus musculus

Gene Type: protein coding

Gene ID: 240873

Summary

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; regulation of T cell activation; and regulation of leukocyte chemotaxis. Located in cell surface. Is expressed in skin; submandibular gland; and thyroid gland. Orthologous to human TNFSF18 (TNF Superfamily member 18). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf18 Products (1)

mRNA	Protein	Name
NM_183391.4	NP_899247.3	tumor necrosis factor ligand superfamily member 18

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18178614	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14647196	MGI
enables tumor necrosis factor receptor superfamily binding	IDA IDA: Inferred from direct assay	14521928	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in T cell proliferation involved in immune response	IDA IDA: Inferred from direct assay	14608036	MGI
NOT involved in activated CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	24107315	MGI
involved in negative regulation of T-helper 17 cell lineage commitment	IMP IMP: Inferred from mutant phenotype	24107315	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	14521928	MGI
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	23892569	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24107315	MGI
NOT involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	24107315	MGI
NOT involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	24107315	MGI
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	24107315	MGI
involved in positive regulation of monocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	24107315	MGI
NOT involved in regulation of CD40 signaling pathway	IMP IMP: Inferred from mutant phenotype	24107315	MGI
involved in regulation of T cell proliferation	IDA IDA: Inferred from direct assay	14608036	MGI
involved in regulation of dendritic cell chemotaxis	IMP IMP: Inferred from mutant phenotype	24107315	MGI
NOT involved in regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	24107315	MGI
NOT involved in regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	24107315	MGI
involved in regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	24107315	MGI
NOT involved in regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	24107315	MGI
NOT involved in regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	24107315	MGI
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	14521928	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	14521928	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tumor necrosis factor ligand superfamily member 18	GITR ligand glucocorticoid-induced TNF-related ligand glucocorticoid-induced-tumor necrosis factor receptor ligand tumor necrosis factor ligand 2a

Tnfsf18 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Tnfsf18	Q7TS55	Tnfsf18	Mus musculus	Q7TS55	X-Ray Diffraction	18178614
Intra	Tnfsf18	Q7TS55	Tnfrsf18	Mus musculus	O35714	Pull Down	14647196
Intra	Tnfsf18	Q7TS55	Tnfrsf18	Mus musculus	O35714	SPR	18182486
Intra	Tnfsf18	Q7TS55	Tnfsf18	Mus musculus	Q7TS55	Solution Sedimentation	18178614
Intra	Tnfsf18	Q7TS55	Tnfsf18	Mus musculus	Q7TS55	GMS	18182486
Intra	Tnfsf18	Q7TS55	Tnfsf18	Mus musculus	Q7TS55	X-Ray Diffraction	18182486

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Tnfsf18 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7319	AITRL/TNFSF18 Protein, Mouse	Q7TS55 (T47-S173)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78299	AITRL/TNFSF18 Protein, Mouse (HEK293, Fc)	Q7TS55 (T47-S173)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991406	MK-1248	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS17260	Tnfsf18 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14827	TNFSF18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23714	Tnfsf18 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991405	EU-102	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnfsf18	NCBI	NCBI:8995