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TNFSF18 - TNF superfamily member 18 Gene

Also Known as TL6; AITRL; GITRL; TNLG2A; hGITRL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8995

About TNFSF18

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,039,202-173,050,941 (from NCBI)

This gene has 1 transcript (splice variant) and 83 orthologues. Broad expression in gall bladder (RPKM 1.2), brain (RPKM 1.0) and 16 other tissues.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

TNFSF18 Products (1)

mRNA	Protein	Name
NM_005092.4	NP_005083.3	tumor necrosis factor ligand superfamily member 18

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18040044	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18040044	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	23892569	GOA
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	23892569	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	23892569	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFSF18 Protein Structure

TNF

0
100
199 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor ligand superfamily member 18	AITR ligand

TNFSF18 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFSF18	Q9UNG2	CUX1	Homo sapiens	P39880	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	CSGALNACT2	Homo sapiens	Q8N6G5	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	TNFSF18	Homo sapiens	Q9UNG2	GMS	18040044
Intra	TNFSF18	Q9UNG2	B4GALT7	Homo sapiens	Q9UBV7	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	CXCR4	Homo sapiens	P61073	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	FUT8	Homo sapiens	Q9BYC5	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	TNFSF18	Homo sapiens	Q9UNG2	Solution Sedimentation	18040044
Intra	TNFSF18	Q9UNG2	ADGRE5	Homo sapiens	P48960	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	TNFRSF18	Homo sapiens	Q9Y5U5	SPR	18040044
Intra	TNFSF18	Q9UNG2	TNFSF18	Homo sapiens	Q9UNG2	GMS	18378892
Intra	TNFSF18	Q9UNG2	ABCB10	Homo sapiens	Q9NRK6	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	FAM171A2	Homo sapiens	A8MVW0	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	TNFSF18	Homo sapiens	Q9UNG2	Crosslink	18378892
Intra	TNFSF18	Q9UNG2	CERS6	Homo sapiens	Q6ZMG9	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	CERS2	Homo sapiens	Q96G23	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	TNFSF18	Homo sapiens	Q9UNG2	Comigration in SDS	18378892
Intra	TNFSF18	Q9UNG2	GOLGA5	Homo sapiens	Q8TBA6	Anti Tag CoIP	33961781
Intra	TNFSF18	Q9UNG2	TNFSF18	Homo sapiens	Q9UNG2	X-Ray Diffraction	18378892
Intra	TNFSF18	Q9UNG2	TNFSF18	Homo sapiens	Q9UNG2	X-Ray Diffraction	18040044

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFSF18 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7318	AITRL/TNFSF18 Protein, Human	Q9UNG2 (E52-I176)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74503	AITRL/TNFSF18 Protein, Human (sf9, His)	Q9UNG2/AAD22634 (E52-S177)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76110	AITRL/TNFSF18 Protein, Human (HEK293, Fc)	Q9UNG2/NP_005083.3 (Q50-S177)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78133	AITRL/TNFSF18 Trimer Protein, Human (Biotinylated, HEK293, His-Flag)	Q9UNG2 (Q50-S177)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78448	AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag)	Q9UNG2 (Q50-S177)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78791	AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q9UNG2 (Q50-S177)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700014AF	Animal-Free AITRL/TNFSF18 Protein, Human (His)	Q9UNG2 (Q50-I174)	≥ 95%, as determined by reducing SDS-PAGE.

TNFSF18 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81770	GITR-L Antibody (YA1515)	FC, ELISA	Human

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991406	MK-1248	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS17260	Tnfsf18 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14827	TNFSF18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23714	Tnfsf18 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991405	EU-102	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNFSF18	VGNC	VGNC:36175
Felis catus	TNFSF18	VGNC	VGNC:107953
Canis familiaris	TNFSF18	VGNC	VGNC:53841
Macaca mulatta	TNFSF18	VGNC	VGNC:78597
Mus musculus	TNFSF18	MGD	MGI:2673064
Rattus norvegicus	TNFSF18	RGD	RGD:1305066
Others	TNFSF18	NCBI