CERS6 - ceramide synthase 6 Gene

Also Known as CERS5; LASS6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 253782

About CERS6

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:168,456,272-168,775,134 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues and 5 paralogues. Ubiquitous expression in colon (RPKM 18.1), thyroid (RPKM 16.4) and 25 other tissues.

Summary

Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

CERS6 Products (2)

mRNA Protein Name
NM_001256126.2 NP_001243055.1 ceramide synthase 6 isoform 1
NM_203463.3 NP_982288.1 ceramide synthase 6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28298427 GOA
enables sphingosine N-acyltransferase activity IDA
IDA: Inferred from direct assay
17609214 GOA
Biological Process GO Annotation Evidence References Source
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
17609214 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CERS6 Protein Structure

Homeobox

Homeobox: Homeobox domain (82 - 125)

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (131 - 324)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

ceramide synthase 6

  • LAG1 homolog, ceramide synthase 6

CERS6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CERS6 Q6ZMG9 OPRL1 Homo sapiens P41146
Ub Reconstruction
28298427
Intra
CERS6 Q6ZMG9 AGTR1 Homo sapiens P30556
Ub Reconstruction
28298427
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hereditary Sensory And Autonomic Neuropathy Type 1

  • Hereditary Sensory And Autonomic Neuropathy Type I

  • Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome

  • Hsan1e

  • Hsan1

  • Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy

  • Hsn1e

  • Hsnie

  • Hereditary Sensory Neuropathy Type Ie

  • Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome

  • Hereditary Sensory And Autonomic Neuropathy Type Ie

  • Hereditary Sensory And Autonomic Neuropathy Type 1e

  • Hereditary Sensory Neuropathy With Hearing Loss And Dementia

  • Dnmt1-Complex Disorder

  • Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss

  • Hsn Ie

  • Hereditary Sensory Autonomic Neuropathy, Type 1

  • Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19542 C6 Ceramide Inducer 99.82% Unkown
HY-RS29482 CERS6 Cattle Pre-designed siRNA Set A / Unkown
HY-133488 ST1072 Inhibitor / Unkown
HY-146905S CER6-2’S-d9 99.0% Unkown
HY-RS02541 CERS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119633 Perfluidone / Unkown
HY-146899S CER6-2’R-d9 99.0% Unkown
HY-W766368 C6 Ceramide-13C2,d2 / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CERS6 MGD MGI:2442564
Canis familiaris CERS6 VGNC VGNC:39152
Rattus norvegicus CERS6 RGD RGD:1561599
Felis catus CERS6 VGNC VGNC:107507
Bos taurus CERS6 VGNC VGNC:27228
Macaca mulatta CERS6 VGNC VGNC:71080
Others CERS6 NCBI