Epor - erythropoietin receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24336

Summary

Enables erythropoietin receptor activity. Involved in several processes, including cellular response to kainic acid; negative regulation of cell death; and negative regulation of nitric oxide biosynthetic process. Located in cytoplasm and external side of plasma membrane. Used to study high grade glioma. Biomarker of several diseases, including brain ischemia; cholangiocarcinoma; end stage renal disease; eye disease (multiple); and hepatic encephalopathy. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Epor Products (1)

mRNA Protein Name
NM_017002.2 NP_058698.2 erythropoietin receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables erythropoietin receptor activity IDA
IDA: Inferred from direct assay
7684373 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to kainic acid IEP
IEP: Inferred from expression pattern
18711747 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
12451129 RGD
involved in negative regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
10489101 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
21749867 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21749867 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
7684373 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
22469063 RGD
involved in positive regulation of response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
23636173 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
21624288 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
27587253 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
21649646 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

erythropoietin receptor

  • EPO-R

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18960 CHZ868 Inhibitor 98.69% Unkown
HY-W062700 STS-E412 Activator 99.72% Unkown
HY-RS04448 EPOR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18356 Epor Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24835 Epor Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108864 Epoetin alfa Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epor NCBI NCBI:2057