Gad1 - glutamate decarboxylase 1 Gene

Also Known as Gad67

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24379

Summary

Enables anion binding activity; glutamate decarboxylase activity; and protein N-terminus binding activity. Involved in gamma-aminobutyric acid biosynthetic process and response to xenobiotic stimulus. Located in presynaptic active zone. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; developmental and epileptic encephalopathy 89; and schizophrenia. Orthologous to human GAD1 (glutamate decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Gad1 Products (1)

mRNA Protein Name
NM_017007.2 NP_058703.1 glutamate decarboxylase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate binding IDA
IDA: Inferred from direct assay
10812196 RGD
enables glutamate decarboxylase activity IDA
IDA: Inferred from direct assay
1924335 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7836456 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
7836456 RGD
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
1880546 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
11259512 RGD
involved in cellular response to serotonin IEP
IEP: Inferred from expression pattern
20881131 RGD
involved in gamma-aminobutyric acid biosynthetic process IDA
IDA: Inferred from direct assay
1924335 RGD
involved in positive regulation of locomotion involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
33293518 RGD
involved in response to auditory stimulus IEP
IEP: Inferred from expression pattern
22428005 RGD
involved in response to caloric restriction IEP
IEP: Inferred from expression pattern
15211593 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
19855903 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
15729141 RGD
involved in response to isolation stress IEP
IEP: Inferred from expression pattern
22356888 RGD
involved in response to methamphetamine hydrochloride IEP
IEP: Inferred from expression pattern
30275762 RGD
involved in response to morphine IEP
IEP: Inferred from expression pattern
15673448 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
19855903 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
23932495 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19359144 RGD
involved in social behavior IMP
IMP: Inferred from mutant phenotype
33293518 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
20659561 RGD
located in presynaptic active zone IDA
IDA: Inferred from direct assay
24613359 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate decarboxylase 1

  • 67 kDa glutamic acid decarboxylase

  • GAD-67

  • Glutamate decarboxylase 1 (brain)

  • glutamate decarboxylase 1 variant GAD67NT

  • glutamic acid decarboxylase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0161A Duloxetine hydrochloride Inhibitor 99.97% Yes
HY-B0161 Duloxetine Inhibitor 99.92% Yes
HY-118901 Opipramol Antagonist 99.91% Unkown
HY-B0161AR Duloxetine hydrochloride (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-122487 Troriluzole Modulator 99.70% Phase 3

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y0367R Maleic acid (Standard) Inhibitor 99.99% Unkown
HY-B0161S Duloxetine-d7 Inhibitor 97.32% Unkown
HY-RS17368 Gad1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118901A Opipramol dihydrochloride Antagonist / Unkown
HY-122487A Troriluzole hydrochloride Modulator / Unkown
HY-B0161AS Duloxetine-d3 hydrochloride Inhibitor / Unkown
HY-B0161AS1 Duloxetine-d7 hydrochloride Inhibitor / Unkown
HY-RS05227 GAD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0161S3 Duloxetine-d5 oxalate Inhibitor / Unkown
HY-RS23822 Gad1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gad1 NCBI NCBI:2571