Got1 - glutamic-oxaloacetic transaminase 1 Gene

Also Known as AAT1; ASAT; cCAT; Aspat; Gaspat; cAspAT

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24401

Summary

Enables L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine:2-oxoglutarate aminotransferase activity; and carboxylic acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; dicarboxylic acid metabolic process; and ion homeostasis. Located in axon terminus; cytosol; and lysosome. Used to study transient cerebral ischemia. Biomarker of cardiomyopathy. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]

Got1 Products (1)

mRNA Protein Name
NM_012571.2 NP_036703.2 aspartate aminotransferase, cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: Inferred from direct assay
2837211 RGD
enables L-aspartate:2-oxoglutarate aminotransferase activity IMP
IMP: Inferred from mutant phenotype
7562489 RGD
enables L-cysteine transaminase activity IDA
IDA: Inferred from direct assay
7113743 RGD
enables carboxylic acid binding IDA
IDA: Inferred from direct assay
2837211 RGD
Biological Process GO Annotation Evidence References Source
involved in L-glutamate biosynthetic process IDA
IDA: Inferred from direct assay
16489927 RGD
involved in aspartate metabolic process IDA
IDA: Inferred from direct assay
2837211 RGD
involved in cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
26880260 RGD
involved in dicarboxylic acid metabolic process IDA
IDA: Inferred from direct assay
2837211 RGD
involved in dicarboxylic acid metabolic process IMP
IMP: Inferred from mutant phenotype
7562489 RGD
involved in glycerol biosynthetic process IDA
IDA: Inferred from direct assay
17545671 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
26880260 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
29215467 RGD
involved in negative regulation of mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
29215467 RGD
involved in oxaloacetate metabolic process IDA
IDA: Inferred from direct assay
16489927 RGD
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26880260 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
29101047 RGD
involved in response to carbohydrate IEP
IEP: Inferred from expression pattern
29101047 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
25451275 RGD
involved in response to transition metal nanoparticle IDA
IDA: Inferred from direct assay
28962237 RGD
involved in transdifferentiation IMP
IMP: Inferred from mutant phenotype
28797105 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
2364283 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aspartate aminotransferase, cytoplasmic

  • aspartate aminotransferase 1

  • cysteine aminotransferase, cytoplasmic

  • cysteine transaminase, cytoplasmic

  • cytosolic aspartate aminotransferase

  • glutamate oxaloacetate transaminase 1, soluble

  • glutamic-oxaloacetic transaminase 1, soluble

  • transaminase A

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0091 Adapalene 99.94% Yes
HY-B0091R Adapalene (Standard) / Unkown
HY-B0091A Adapalene sodium salt 99.69% Yes

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160818 MC3138 Activator 99.92% Unkown
HY-122723 GOT1 inhibitor-1 Inhibitor 98.75% Unkown
HY-124825 iGOT1-01 Inhibitor 99.18% Unkown
HY-N3307 (+)-Medioresinol 99.13% Unkown
HY-RS05605 GOT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N6237 Aspulvinone O ≥96.0% Unkown
HY-B0091S Adapalene-d3 / Unkown
HY-RS05596 GOLT1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W752012 Adapalene-13C6 / Unkown
HY-N14093 Aspulvinone H / Unkown
HY-RS16967 Got1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23410 Got1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Got1 NCBI NCBI:2805