GOT1 - glutamic-oxaloacetic transaminase 1 Gene

Also Known as AST; AST1; SGOT; cCAT; GIG18; cAspAT; ASTQTL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2805

About GOT1

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:99,396,870-99,430,624 (from NCBI)

This gene has 3 transcripts (splice variants), 274 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in heart (RPKM 196.1), liver (RPKM 87.7) and 14 other tissues.

Summary

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two Enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

GOT1 Products (1)

mRNA Protein Name
NM_002079.3 NP_002070.1 aspartate aminotransferase, cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: Inferred from direct assay
2182221 GOA
Biological Process GO Annotation Evidence References Source
involved in aspartate catabolic process IDA
IDA: Inferred from direct assay
2241899 GOA
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
8396422 GOA
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
8396422 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
7060339 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOT1 Protein Structure

Aminotran_1_2

Aminotran_1_2: Aminotransferase class I and II (32 - 405)

  • 0
  • 100
  • 200
  • 300
  • 413 a.a.
Protein Preferred Names Protein Names

aspartate aminotransferase, cytoplasmic

  • aspartate aminotransferase 1

Recombinant GOT1 Proteins

Cat. No. Product Name Accession Purity
HY-P7611 GOT1 Protein, Human (His) P17174-1 (A2-Q413) ≥ 95%, as determined by reducing SDS-PAGE.

GOT1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82430 Aspartate Aminotransferase Antibody (YA2175) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82430A Aspartate Aminotransferase Antibody (YA2175)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1

  • Astqtl1

  • Aspartate Aminotransferase, Serum Level Of, Qtl1
Siderosis

  • Pulmonary Siderosis

  • Deposition Of Iron

  • Arc-Welders' Disease

  • Arc-Welders' Lung

  • Arc-Welders' Nodulation

  • Arc-Welders' Pneumoconiosis

  • Iron Oxide Lung

  • Iron Pneumoconiosis

  • Pneumoconiosis Siderotico

  • Siderotic Lung Disease

  • Steel Grinders' Disease

  • Welders' Lung

  • Welders' Siderosis

  • Lung Fibrosis With Siderosis
Acute Thyroiditis

  • Infectious Thyroiditis
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Hepatic Coma

  • Hepatic Encephalopathy

  • Hepatocerebral Intoxication
Hemophagocytic Lymphohistiocytosis, Familial, 3

  • Familial Hemophagocytic Lymphohistiocytosis 3

  • FHL3

  • Hplh3

  • Hlh3

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 3
Osteopetrosis

  • Marble Bone Disease

  • Albers-Schonberg Disease

  • Osteopetroses

  • Marble Bones

  • Osteopetrosis And Related Disorders

  • Congenital Osteopetrosis

  • Marble Bone

  • Albers-Schoenberg Disease

  • Albers-Schonberg Osteopetrosis

  • Osteosclerosis Fragilis

  • Ivory Bones
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Myelodysplastic Syndrome

  • Myelodysplastic Syndromes

  • Myelodysplasia

  • MDS

  • Myelodysplastic Syndrome Included

  • Myelodysplastic Syndrome, Susceptibility To, Included

  • Myelodysplastic Syndrome, Somatic

  • Myelodysplastic Syndrome, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0091 Adapalene 99.94% Yes
HY-B0091R Adapalene (Standard) / Unkown
HY-B0091A Adapalene sodium salt 99.69% Yes

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160818 MC3138 Activator 99.92% Unkown
HY-122723 GOT1 inhibitor-1 Inhibitor 98.75% Unkown
HY-124825 iGOT1-01 Inhibitor 99.18% Unkown
HY-N3307 (+)-Medioresinol 99.13% Unkown
HY-RS05605 GOT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N6237 Aspulvinone O ≥96.0% Unkown
HY-B0091S Adapalene-d3 / Unkown
HY-RS05596 GOLT1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W752012 Adapalene-13C6 / Unkown
HY-N14093 Aspulvinone H / Unkown
HY-RS16967 Got1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23410 Got1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GOT1 VGNC VGNC:67398
Rattus norvegicus GOT1 RGD RGD:2721
Bos taurus GOT1 VGNC VGNC:29501
Canis familiaris GOT1 VGNC VGNC:41354
Macaca mulatta GOT1 VGNC VGNC:73111
Mus musculus GOT1 MGD MGI:95791
Others GOT1 NCBI