Hdc - histidine decarboxylase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24443

Summary

Enables several functions, including histidine decarboxylase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Involved in histamine metabolic process and histidine metabolic process. Located in cytosol; dendrite; and neuronal cell body. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]

Hdc Products (1)

mRNA Protein Name
NM_017016.2 NP_058712.2 histidine decarboxylase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amino acid binding IDA
IDA: Inferred from direct assay
5898 RGD
enables histidine decarboxylase activity IDA
IDA: Inferred from direct assay
5898 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
14622303 RGD
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
5898 RGD
Biological Process GO Annotation Evidence References Source
involved in L-histidine metabolic process IDA
IDA: Inferred from direct assay
5898 RGD
involved in histamine metabolic process IDA
IDA: Inferred from direct assay
5898 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
2458167 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
2458167 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histidine decarboxylase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W003445 4-Bromo-3-hydroxybenzoic acid 99.25% Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-186122 CCK2R agonist-1 Agonist / Unkown
HY-RS06091 HDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06106 HECA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W194107 Antitumor agent-152 Inhibitor / Unkown
HY-RS17727 Hdc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24192 Hdc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdc NCBI NCBI:3067
Mus musculus Hdc NCBI NCBI:15186