Hmgcs2 - 3-hydroxy-3-methylglutaryl-CoA synthase 2 Gene

Also Known as Hmgcs1; Mt3h3mg

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24450

Summary

Enables hydroxymethylglutaryl-CoA synthase activity. Involved in several processes, including animal organ development; cellular response to lipid; and response to peptide hormone. Located in mitochondrial matrix. Biomarker of extrahepatic cholestasis. Orthologous to human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcs2 Products (1)

mRNA Protein Name
NM_173094.2 NP_775117.2 hydroxymethylglutaryl-CoA synthase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hydroxymethylglutaryl-CoA synthase activity IDA
IDA: Inferred from direct assay
1971108 RGD
Biological Process GO Annotation Evidence References Source
involved in adipose tissue development IEP
IEP: Inferred from expression pattern
10357839 RGD
involved in cellular response to amino acid stimulus IEP
IEP: Inferred from expression pattern
20508999 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
20508999 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
9798904 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
9025717 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
12027802 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
11578593 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
7694571 RGD
involved in ketone body biosynthetic process IEP
IEP: Inferred from expression pattern
12399220 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
8099282 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
8620869 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
7911291 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
8620869 RGD
involved in multicellular organismal response to stress IEP
IEP: Inferred from expression pattern
16962226 RGD
involved in response to bacterium IEP
IEP: Inferred from expression pattern
14686922 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
7902069 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17964421 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
10796071 RGD
involved in response to glucagon IEP
IEP: Inferred from expression pattern
1967579 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
9546617 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
11551854 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
9143333 RGD
involved in response to linoleic acid IEP
IEP: Inferred from expression pattern
16216487 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
8100835 RGD
involved in response to monosaccharide IEP
IEP: Inferred from expression pattern
1967579 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
17103110 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20137896 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
12027802 RGD
involved in response to prostaglandin F IEP
IEP: Inferred from expression pattern
11517196 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
10357839 RGD
involved in response to temperature stimulus IEP
IEP: Inferred from expression pattern
10357839 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
10357839 RGD
involved in response to triglyceride IEP
IEP: Inferred from expression pattern
11551854 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11323196 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
17971398 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hydroxymethylglutaryl-CoA synthase, mitochondrial

  • 3-hydroxy-3-methylglutary-Coenzyme A synthase 2

  • 3-hydroxy-3-methylglutaryl coenzyme A synthase

  • 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

  • 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)

  • HMG-CoA synthase

  • hydroxymethylgl

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148334 MS8815 Degrader 99.95% Unkown
HY-RS06242 HMGCS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18424 Hmgcs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24905 Hmgcs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgcs2 NCBI NCBI:3158