Il1a - interleukin 1 alpha Gene

Also Known as IL-1F1; IL-1 alpha

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24493

About Il1a

Primary_assembly 3: 116,526,604-116,536,822 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 92 orthologues and is associated with 116 phenotypes. Biased expression in Liver (RPKM 64.8), Lung (RPKM 41.1) and 6 other tissues.

Summary

Predicted to enable copper ion binding activity; cytokine activity; and interleukin-1 receptor binding activity. Involved in several processes, including keratinization; negative regulation of establishment of Sertoli cell barrier; and positive regulation of intracellular signal transduction. Located in several cellular components, including cell surface; cytosol; and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Il1a Products (1)

mRNA Protein Name
NM_017019.2 NP_058715.1 interleukin-1 alpha

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in heart development IEP
IEP: Inferred from expression pattern
1297459 RGD
involved in keratinization IDA
IDA: Inferred from direct assay
20385541 RGD
involved in negative regulation of establishment of Sertoli cell barrier IDA
IDA: Inferred from direct assay
18057314 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
16595703 RGD
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
15671867 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15671867 RGD
acts upstream of positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
31172560 RGD
acts upstream of positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
31172560 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
17621543 RGD
involved in positive regulation of neutrophil migration IMP
IMP: Inferred from mutant phenotype
1826836 RGD
involved in positive regulation of prostaglandin secretion IDA
IDA: Inferred from direct assay
8612624 RGD
involved in positive regulation of steroid biosynthetic process IDA
IDA: Inferred from direct assay
16595703 RGD
involved in positive regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
15671867 RGD
acts upstream of positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
31172560 RGD
involved in regulation of actin cytoskeleton organization IDA
IDA: Inferred from direct assay
18057314 RGD
involved in response to L-ascorbic acid IEP
IEP: Inferred from expression pattern
18983910 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
16524844 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15197744 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19524137 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16087301 RGD
involved in response to ozone IEP
IEP: Inferred from expression pattern
17901407 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
7859917 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
17621543 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12270120 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il1a Protein Structure

IL1_propep

IL1_propep: pfam02394 (0 - 110)

IL1

IL1: smart00125 (130 - 269)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

interleukin-1 alpha

Recombinant Il1a Proteins

Cat. No. Product Name Accession Purity
HY-P7096 IL-1 alpha Protein, Rat (CHO) P16598 (A116-S270) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72572 IL-1 alpha Protein, Rat P16598 (S115-S270) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171657 4'-Acetoxy resveratrol 99.90% Unkown
HY-P4542 (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) Antagonist / Unkown
HY-RS06713 IL1A Human Pre-designed siRNA Set A / Unkown
HY-RS06714 Il1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06715 Il1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174628 Human IL1A mRNA / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99138 Anti-Mouse IL-1a Antibody (ALF-161) Inhibitor ≥95.0% Unkown
HY-P991008 Lunlekitug Inhibitor 99.9% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1a NCBI NCBI:3552