2. Gene
  3. Il1a - interleukin 1 alpha Gene

Il1a - interleukin 1 alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as IL-1F1; IL-1 alpha

Gene ID: 24493 | Gene type: protein coding

About Il1a

Primary_assembly 3: 116,526,604-116,536,822 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 92 orthologues and is associated with 116 phenotypes. Biased expression in Liver (RPKM 64.8), Lung (RPKM 41.1) and 6 other tissues.

Summary

Predicted to enable copper ion binding activity; cytokine activity; and interleukin-1 receptor binding activity. Involved in several processes, including keratinization; negative regulation of establishment of Sertoli cell barrier; and positive regulation of intracellular signal transduction. Located in several cellular components, including cell surface; cytosol; and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Il1a Products(1)

mRNA Protein Name
NM_017019.2 NP_058715.1 interleukin-1 alpha

Il1a Protein Structure

IL1_propep

IL1_propep: pfam02394 (0 - 110)

IL1

IL1: smart00125 (130 - 269)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

interleukin-1 alpha

Recombinant Il1a Proteins

Cat. No. Product Name Accession Purity
HY-P7096 IL-1 alpha Protein, Rat (CHO) P16598-1 (A116-S270) ≥95%
HY-P72572 IL-1 alpha Protein, Rat P16598 (S115-S270) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P4542 (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) Antagonist / Unkown
HY-RS06713 IL1A Human Pre-designed siRNA Set A / Unkown
HY-RS06714 Il1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS06715 Il1a Rat Pre-designed siRNA Set A / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99138 Anti-Mouse IL-1a Antibody (ALF-161) Inhibitor ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1a NCBI NCBI:3552
Macaca fascicularis Il1a NCBI NCBI:101926546
Mus musculus Il1a NCBI NCBI:16175
Susscrofa domestica Il1a NCBI
Macaca mulatta Il1a NCBI NCBI:700193