Jund - JunD proto-oncogene, AP-1 transcription factor subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24518

Summary

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and Apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

Jund Products (2)

mRNA	Protein	Name
NM_001286966.2	NP_001273895.1	transcription factor JunD isoform deltaJunD
NM_138875.5	NP_620230.1	transcription factor JunD isoform JunD-FL

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10523647	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12105216	RGD
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	10830307	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	10830307	RGD
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	15860571	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10830307	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	10523647	RGD
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	22275377	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	30629164	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	8593588	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	10987819	RGD
involved in positive regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	18443593	RGD
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	30629164	RGD
involved in regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	22275377	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12105216	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	11146118	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11389931	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	16373449	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11113530	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	10934195	RGD
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10830307	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IDA IDA: Inferred from direct assay	10523647	RGD
part of protein-DNA complex	IDA IDA: Inferred from direct assay	10523647	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15860571	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor JunD	jun D proto-oncogene transcription factor AP-1 subunit JunD transcription factor jun-D

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07060	JUND Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19345	Jund Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179594	HTS10307	Inhibitor	/	Unkown
HY-182050	YL0441	Inhibitor	/	Unkown
HY-W471288	JPC0661	Inhibitor	/	Unkown
HY-N11231	Fucoxanthinol		/	Unkown
HY-RS25836	Jund Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Jund	NCBI	NCBI:3727