Lcat - lecithin cholesterol acyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24530

Summary

Enables phosphatidylcholine-sterol O-acyltransferase activity and Phospholipase A2 activity. Involved in several processes, including Cholesterol metabolic process; response to copper ion; and response to glucocorticoid. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Used to study end stage renal disease; familial hyperlipidemia; and myocardial infarction. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol Acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Lcat Products (1)

mRNA Protein Name
NM_017024.2 NP_058720.2 phosphatidylcholine-sterol acyltransferase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphatidylcholine-sterol O-acyltransferase activity IDA
IDA: Inferred from direct assay
9219904 RGD
enables phospholipase A2 activity IDA
IDA: Inferred from direct assay
9219904 RGD
Biological Process GO Annotation Evidence References Source
involved in aflatoxin metabolic process IEP
IEP: Inferred from expression pattern
28959666 RGD
involved in cholesterol metabolic process IDA
IDA: Inferred from direct assay
746355 RGD
involved in lipoprotein metabolic process IDA
IDA: Inferred from direct assay
3918579 RGD
involved in response to copper ion IDA
IDA: Inferred from direct assay
7288494 RGD
involved in response to glucocorticoid IDA
IDA: Inferred from direct assay
1420288 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylcholine-sterol acyltransferase

  • 1-alkyl-2-acetylglycerophosphocholine esterase

  • Lecithin-cholesterol acyltransferase

  • PAF acetylhydrolase

  • phospholipid-cholesterol acyltransferase

  • platelet-activating factor acetylhydrolase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-113202S Stearoyl-L-carnitine-d3 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153169 6PPD-Q Inhibitor 99.77% Unkown
HY-P5282 ApoA-I mimetic peptide Activator 98.90% Unkown
HY-113202 Stearoylcarnitine Inhibitor 99.91% Unkown
HY-RS07549 LCAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113202S1 Stearoyl-L-carnitine-d9 chloride Inhibitor / Unkown
HY-RS17454 Lcat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23910 Lcat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992256 Anti-LCAT Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lcat NCBI NCBI:3931