Ncam1 - neural cell adhesion molecule 1 Gene

Also Known as Cd56; Ncam; N-CAM; NCAMC; NCAM-1; NCAM-C; N-CAM-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24586

Summary

Enables LRR domain binding activity and Phosphatase binding activity. Involved in several processes, including axon development; positive regulation of cardiac muscle cell proliferation; and thalamus development. Located in neuronal cell body and plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study middle cerebral artery infarction. Biomarker of Alzheimer's disease; congestive heart failure; hypothyroidism; mental depression; and myocardial infarction. Human ortholog(s) of this gene implicated in bipolar disorder; middle cerebral artery infarction; and pancreatic Cancer. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncam1 Products (5)

mRNA Protein Name
NM_001395707.1 NP_001382636.1 neural cell adhesion molecule 1 isoform 1 precursor
NM_001395708.1 NP_001382637.1 neural cell adhesion molecule 1 isoform 2 precursor
NM_001395709.1 NP_001382638.1 neural cell adhesion molecule 1 isoform 3 precursor
NM_001395710.1 NP_001382639.1 neural cell adhesion molecule 1 isoform 4 precursor
NM_031521.3 NP_113709.1 neural cell adhesion molecule 1 isoform 5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables LRR domain binding IPI
IPI: Inferred from physical interaction
15865439 RGD
enables phosphatase binding IDA
IDA: Inferred from direct assay
15865439 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15865439 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16609270 RGD
involved in axonal fasciculation IMP
IMP: Inferred from mutant phenotype
3856258 RGD
involved in behavioral response to ethanol IEP
IEP: Inferred from expression pattern
16207289 RGD
involved in cellular response to ethanol IDA
IDA: Inferred from direct assay
10936176 RGD
involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
16207289 RGD
involved in cellular response to fluoride IEP
IEP: Inferred from expression pattern
17537562 RGD
involved in cellular response to molecule of bacterial origin IEP
IEP: Inferred from expression pattern
19853610 RGD
involved in learning or memory IDA
IDA: Inferred from direct assay
18702715 RGD
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
18194217 RGD
involved in medium-term memory IEP
IEP: Inferred from expression pattern
16207289 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
7997264 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
7997264 RGD
involved in multicellular organismal response to stress IDA
IDA: Inferred from direct assay
17429411 RGD
involved in negative regulation of programmed cell death IMP
IMP: Inferred from mutant phenotype
18757519 RGD
involved in neuron development IDA
IDA: Inferred from direct assay
16958105 RGD
involved in peripheral nervous system axon regeneration IEP
IEP: Inferred from expression pattern
15679872 RGD
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19853610 RGD
involved in regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
26821693 RGD
involved in regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24399412 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
12499861 RGD
involved in response to cocaine IDA
IDA: Inferred from direct assay
16081054 RGD
involved in response to lead ion IDA
IDA: Inferred from direct assay
18499259 RGD
involved in response to morphine IEP
IEP: Inferred from expression pattern
15673448 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
16207289 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
17307340 RGD
involved in thalamus development IDA
IDA: Inferred from direct assay
17292800 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
7997264 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
7997264 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
10936176 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
2592994 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16216431 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
2592994 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
2592994 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neural cell adhesion molecule 1

Recombinant Ncam1 Proteins

Cat. No. Product Name Accession Purity
HY-P73749 NCAM-1/CD56 Protein, Rat (HEK293, His) P13596 (L20-T721) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99372 Lorvotuzumab 99.77% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09063 NCAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17707 Ncam1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24172 Ncam1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncam1 NCBI NCBI:4684