2. Gene
  3. Nos3 - nitric oxide synthase 3 Gene

Nos3 - nitric oxide synthase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as eNos

Gene ID: 24600 | Gene type: protein coding

About Nos3

Primary_assembly 4: 10,793,834-10,814,166 reverse strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 114 orthologues, 5 paralogues and is associated with 177 phenotypes. Biased expression in Heart (RPKM 114.2), Spleen (RPKM 51.1) and 8 other tissues.

Summary

Enables several functions, including HSP90 protein binding activity; beta-catenin binding activity; and Calmodulin binding activity. Involved in several processes, including cellular response to magnesium ion; cellular response to mechanical stimulus; and cellular response to organonitrogen compound. Located in several cellular components, including caveola; nucleolus; and sarcolemma. Used to study artery disease (multiple); irritable bowel syndrome; ischemia (multiple); liver disease (multiple); and retinal disease (multiple). Biomarker of several diseases, including artery disease (multiple); kidney failure (multiple); liver disease (multiple); lung disease (multiple); and overnutrition (multiple). Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ Cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3). [provided by Alliance of Genome Resources, Apr 2022]

Nos3 Products(1)

mRNA Protein Name
NM_021838.2 NP_068610.1 nitric oxide synthase, endothelial

Nos3 Protein Structure

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (66 - 478)

Flavodoxin_1

Flavodoxin_1: pfam00258 (520 - 696)

FNR_like

FNR_like: cl06868 (760 - 1162)

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  • 1202 a.a.
Protein Preferred Names Protein Names

nitric oxide synthase, endothelial

EC-NOS

NOS type III

NOSIII

cNOS

constitutive NOS

endothelial NOS

endothelial nitric oxide synthase 3

nitric oxide synthase 3, endothelial cell

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18732A L-NMMA acetate Inhibitor 98.58% Phase 4
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09440 NOS3 Human Pre-designed siRNA Set A / Unkown
HY-RS09441 Nos3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09442 Nos3 Rat Pre-designed siRNA Set A / Unkown
HY-N8761 Kihadanin A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nos3 NCBI NCBI:4846