Tp63 - tumor protein p63 Gene

Also Known as Ket; P73l; Tp73l; Trp63

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246334

Summary

This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and Apoptosis. The family members can interact with each Other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]

Tp63 Products (6)

mRNA Protein Name
NM_001127339.2 NP_001120811.1 tumor protein 63 isoform b
NM_001127341.1 NP_001120813.1 tumor protein 63 isoform c
NM_001127342.3 NP_001120814.1 tumor protein 63 isoform d
NM_001127343.3 NP_001120815.1 tumor protein 63 isoform e
NM_001127344.2 NP_001120816.1 tumor protein 63 isoform f
NM_019221.4 NP_062094.1 tumor protein 63 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11470269 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
11850815 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11850815 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
15292098 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor protein 63

  • keratinocyte transcription factor KET

  • transformation related protein 63

  • tumor protein 63 kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14923 TP63 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19962 Tcp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24853 Tp63 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tp63 NCBI NCBI:8626