Pfkfb1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

Also Known as PFRX; Pfkfb01

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24638

Summary

Enables several functions, including 6-phosphofructo-2-kinase activity; anion binding activity; and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in several processes, including carbohydrate phosphorylation; positive regulation of Glucokinase activity; and response to peptide hormone. Part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Biomarker of hyperinsulinism. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pfkfb1 Products (3)

mRNA Protein Name
NM_001271063.1 NP_001257992.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001271064.1 NP_001257993.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 3
NM_012621.4 NP_036753.4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 6-phosphofructo-2-kinase activity IDA
IDA: Inferred from direct assay
7619077 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
7619077 RGD
enables fructose-2,6-bisphosphate 2-phosphatase activity IDA
IDA: Inferred from direct assay
7619077 RGD
enables fructose-6-phosphate binding IDA
IDA: Inferred from direct assay
7619077 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
7619077 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
8634242 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
11522786 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
1315037 RGD
involved in carbohydrate phosphorylation IDA
IDA: Inferred from direct assay
7619077 RGD
involved in positive regulation of glucokinase activity IMP
IMP: Inferred from mutant phenotype
15047617 RGD
involved in positive regulation of glycolytic process through fructose-6-phosphate IMP
IMP: Inferred from mutant phenotype
12230553 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
7593243 RGD
involved in response to glucagon IEP
IEP: Inferred from expression pattern
7593243 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
7593243 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
8131849 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
9705027 RGD
Cellular Component GO Annotation Evidence References Source
part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex IDA
IDA: Inferred from direct assay
7619077 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

  • 6-PF2-K/Fru-2,6-P2ase

  • 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase

  • 6PF-2-K/Fru-2,6-P2ASE liver isozyme

  • 6PF-2-K/Fru-2,6-P2ase 1

  • PFK/FBPase 1

  • PFK2/FBPase2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101972 AZ-PFKFB3-67 Inhibitor 97.03% Unkown
HY-101971 AZ PFKFB3 26 Inhibitor 99.23% Unkown
HY-178367 PFKFB4-IN-1 99.91% Unkown
HY-101972A AZ-PFKFB3-67 quarterhydrate Inhibitor 99.0% Unkown
HY-184148 PFKFB3-IN-3 Inhibitor / Unkown
HY-RS10361 PFKFB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20187 Pfkfb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26691 Pfkfb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfkfb1 NCBI NCBI:5207