Prlr - prolactin receptor Gene

Also Known as RATPRLR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24684

Summary

Enables Prolactin receptor activity and protein kinase binding activity. Predicted to be involved in several processes, including activation of protein kinase activity; cytokine-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including gland development; receptor signaling pathway via JAK-STAT; and response to bacterium. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (Prolactin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Prlr Products (2)

mRNA Protein Name
NM_001034111.1 NP_001029283.1 prolactin receptor isoform a precursor
NM_012630.2 NP_036762.1 prolactin receptor isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables prolactin receptor activity IMP
IMP: Inferred from mutant phenotype
11835322 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
7935483 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus IMP
IMP: Inferred from mutant phenotype
8650199 RGD
involved in positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
8650199 RGD
involved in positive regulation of protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
8650199 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolactin receptor

  • PRL-R

  • lactogen receptor

Recombinant Prlr Proteins

Cat. No. Product Name Accession Purity
HY-P73693 Prolactin Receptor Protein, Rat (HEK293, His) P05710 (Q20-D229) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991358 XOMA-213 Inhibitor 98.46% Phase 1
HY-P99881 Rolinsatamab talirine / Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11163 PRLR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11411 PTP4A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17413 Prlr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23867 Prlr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99238 Rolinsatamab 96.98% Unkown
HY-P992449 REGN2878 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prlr NCBI NCBI:5618