Rara - retinoic acid receptor, alpha Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24705

About Rara

Primary_assembly 10: 83,893,384-83,928,142 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 331 orthologues, 19 paralogues and is associated with 12 phenotypes. Biased expression in Lung (RPKM 12.3), Kidney (RPKM 75.) and 9 other tissues.

Summary

Enables histone deacetylase binding activity; nucleic acid binding activity; and phosphatidylinositol 3-kinase regulator activity. Involved in several processes, including animal organ development; positive regulation of intracellular signal transduction; and response to vitamin A. Located in dendrite; nucleus; and perinuclear region of cytoplasm. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human RARA (retinoic acid receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Rara Products (1)

mRNA Protein Name
NM_031528.2 NP_113716.2 retinoic acid receptor alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heterocyclic compound binding IDA
IDA: Inferred from direct assay
19100254 RGD
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
21383775 RGD
enables mRNA 5'-UTR binding IDA
IDA: Inferred from direct assay
19073915 RGD
enables mRNA regulatory element binding translation repressor activity IDA
IDA: Inferred from direct assay
19073915 RGD
Biological Process GO Annotation Evidence References Source
involved in female pregnancy IEP
IEP: Inferred from expression pattern
18342837 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
18619947 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
15388488 RGD
involved in male gonad development IDA
IDA: Inferred from direct assay
14613895 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12704731 RGD
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
19073915 RGD
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
19100254 RGD
involved in prostate gland development IEP
IEP: Inferred from expression pattern
12193579 RGD
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
12186877 RGD
involved in regulation of myelination IDA
IDA: Inferred from direct assay
20648638 RGD
involved in regulation of synaptic plasticity IDA
IDA: Inferred from direct assay
18957222 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
17078027 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
12193579 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
12954654 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
18384703 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
19073915 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12193579 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rara Protein Structure

NR_DBD_RAR

NR_DBD_RAR: cd06964 (81 - 165)

NR_LBD_RAR

NR_LBD_RAR: cd06937 (185 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

retinoic acid receptor alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101106 AR7 Antagonist 99.38% Unkown
HY-172399 FTO-IN-14 / Unkown
HY-179267 FTO-IN-16 / Unkown
HY-RS11669 RARA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11670 Rara Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11671 Rara Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rara NCBI NCBI:5914