Scn2a - sodium voltage-gated channel alpha subunit 2 Gene

Also Known as SCN; ScpII; NachII; Nav1.2; Scn2a1; Scn2a2; RII/RIIA; RNSCPIIR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24766

About Scn2a

Primary_assembly 3: 50,302,877-50,437,214 forward strand.mRatBN7.2:CM026976.1

This gene has 5 transcripts (splice variants), 130 orthologues, 26 paralogues and is associated with 41 phenotypes. Restricted expression toward (RPKM 552.3).

Summary

Voltage-gated sodium channels are Transmembrane Glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the Sodium Channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. [provided by RefSeq, Nov 2016]

Scn2a Products (1)

mRNA Protein Name
NM_012647.2 NP_036779.2 sodium channel protein type 2 subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables leucine zipper domain binding IPI
IPI: Inferred from physical interaction
17360357 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10737807 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
25615535 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
25615535 RGD
enables voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
2442385 RGD
Biological Process GO Annotation Evidence References Source
involved in axon development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
28029095 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in corpus callosum development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in myelination IEP
IEP: Inferred from expression pattern
16652168 RGD
involved in neuronal action potential IDA
IDA: Inferred from direct assay
15917456 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
28029095 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
2442385 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
22473424 RGD
located in axon initial segment IDA
IDA: Inferred from direct assay
12036953 RGD
located in node of Ranvier IDA
IDA: Inferred from direct assay
16652168 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
24297919 RGD
part of voltage-gated sodium channel complex IDA
IDA: Inferred from direct assay
2442385 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn2a Protein Structure

Ion_trans

Ion_trans: pfam00520 (127 - 434)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (557 - 708)

Ion_trans

Ion_trans: pfam00520 (757 - 970)

Na_trans_assoc

Na_trans_assoc: pfam06512 (996 - 1202)

Ion_trans

Ion_trans: pfam00520 (1206 - 1481)

Na_channel_gate

Na_channel_gate: cd13433 (1473 - 1525)

Ion_trans

Ion_trans: pfam00520 (1530 - 1785)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2005 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 2 subunit alpha

  • RIIA sodium channel protein

  • sodium channel protein type II subunit alpha

  • sodium channel protein, brain II subunit alpha

  • sodium channel voltage-gated type II alpha polypeptide

  • sodium channel, voltage-gated, type 2, alpha 1 polypeptide

  • sodium channel, voltage-gated, type 2, alpha 1 subunit

  • sodium channel, voltage-gated, type II, alpha 1

  • sodium channel, voltage-gated, type II, alpha subunit

  • voltage-gated sodium channel subunit alpha Nav1.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150514 ARN1468 Inhibitor 98.96% Unkown
HY-W081348 1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one Inhibitor 99.54% Unkown
HY-107662 TCS PrP Inhibitor 13 Inducer 99.72% Unkown
HY-RS12529 SCN2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12530 Scn2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12531 Scn2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12535 Scn3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12550 Scn9a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn2a NCBI NCBI:6326