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Elsunersen

(Synonyms: PRAX-222)

Elsunersen (PRAX‑222) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen reduces the protein level of the voltage-gated sodium channel NaV1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability. Elsunersen combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen can be used in research related to epileptic encephalopathy.

For research use only. We do not sell to patients.

  • CAS No.: 2756001-75-7
  • Formula: C230H320N67O126P19S13
  • Molecular Weight:7044.71
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Elsunersen Chemical Structure
    Elsunersen Chemical Structure
CAS No.: 2756001-75-7
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Use of MCE Products

All Sodium Channel Isoforms

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All DNA/RNA Synthesis Isoforms

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  • Elsunersen Chemical Structure
    Elsunersen Chemical Structure DNA, d([2′-O-(2-methoxyethyl)](m5rC-sp-m5rC-rA-m5rC-rG-rA)-m5C-sp-A-sp-T-sp-A-sp-T-sp-T-sp-T-sp-T-sp-T-sp-m5C-sp-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rA)
    1/16
  • DNA, d([2′-O-(2-methoxyethyl)](m5rC-sp-m5rC-rA-m5rC-rG-rA)-m5C-sp-A-sp-T-sp-A-sp-T-sp-T-sp-T-sp-T-sp-T-sp-m5C-sp-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rA)