Abcb4 - ATP binding cassette subfamily B member 4 Gene

Also Known as Mdr2; Pgy3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24891

Summary

Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in response to glucocorticoid and response to xenobiotic stimulus. Located in Golgi membrane and apical plasma membrane. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Apr 2022]

Abcb4 Products (1)

mRNA Protein Name
NM_012690.2 NP_036822.1 phosphatidylcholine translocator ABCB4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15159385 RGD
Biological Process GO Annotation Evidence References Source
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
12429353 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
10464145 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
10748167 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10748167 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylcholine translocator ABCB4

  • ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2)

  • ATP-binding cassette sub-family B member 4

  • ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2)

  • ATP-binding cas

Abcb4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Abcb4 Q08201 Hax1 Rattus norvegicus Q7TSE9
Pull Down
15159385
Intra
Abcb4 Q08201 Hax1 Rattus norvegicus Q7TSE9
Y2H
15159385
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183032 ABC transporter modulator-1 Activator 96.30% Unkown
HY-183033 ABC transporter modulator-2 Activator / Unkown
HY-183034 ABC transporter modulator-3 Activator 97.0% Unkown
HY-183035 ABC transporter modulator-4 Modulator / Unkown
HY-183036 ABC transporter modulator-5 Modulator / Unkown
HY-RS00051 ABCB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21466 Abcb4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27984 Abcb4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcb4 NCBI NCBI:5244