Ptn - pleiotrophin Gene

Also Known as HARP; Hbnf

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24924

Summary

Enables several functions, including glycosaminoglycan binding activity; growth factor activity; and syndecan binding activity. Involved in several processes, including animal organ development; nervous system development; and regulation of epithelial cell proliferation. Located in several cellular components, including basement membrane; neuromuscular junction; and perinuclear region of cytoplasm. Is active in postsynapse and presynapse. Used to study Parkinson's disease. Biomarker of several diseases, including extrahepatic cholestasis; liver cirrhosis; sciatic neuropathy; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in adrenal carcinoma. Orthologous to human PTN (pleiotrophin). [provided by Alliance of Genome Resources, Apr 2022]

Ptn Products (1)

mRNA Protein Name
NM_017066.3 NP_058762.1 pleiotrophin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chondroitin sulfate proteoglycan binding IPI
IPI: Inferred from physical interaction
20369290 RGD
enables glycosaminoglycan binding IDA
IDA: Inferred from direct assay
7925491 RGD
enables growth factor activity IDA
IDA: Inferred from direct assay
16226713 RGD
enables heparan sulfate binding IPI
IPI: Inferred from physical interaction
8567685 RGD
enables heparin binding IDA
IDA: Inferred from direct assay
16226713 RGD
enables heparin binding IPI
IPI: Inferred from physical interaction
8567685 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8175719 RGD
enables proteoglycan binding IPI
IPI: Inferred from physical interaction
8702927 RGD
enables syndecan binding IPI
IPI: Inferred from physical interaction
9817766 RGD
enables vascular endothelial growth factor binding IPI
IPI: Inferred from physical interaction
17881084 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to UV IEP
IEP: Inferred from expression pattern
17925408 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
16226713 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
12057922 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
16226713 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
21153232 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
8653419 RGD
involved in dendrite regeneration IDA
IDA: Inferred from direct assay
27671118 RGD
involved in endothelial cell differentiation IEP
IEP: Inferred from expression pattern
20830586 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
9846168 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
17925408 RGD
involved in hindbrain development IEP
IEP: Inferred from expression pattern
9749725 RGD
involved in learning IEP
IEP: Inferred from expression pattern
24069387 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
12057922 RGD
involved in long-term synaptic potentiation IEP
IEP: Inferred from expression pattern
8904779 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
2270483 RGD
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
17881084 RGD
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17881084 RGD
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
8812110 RGD
involved in negative regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
17881084 RGD
involved in negative regulation of membrane potential IDA
IDA: Inferred from direct assay
9753126 RGD
involved in negative regulation of mesenchymal cell proliferation IDA
IDA: Inferred from direct assay
8812110 RGD
involved in negative regulation of neuromuscular junction development IDA
IDA: Inferred from direct assay
7722643 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17925408 RGD
involved in positive regulation of axon regeneration IDA
IDA: Inferred from direct assay
27671118 RGD
involved in positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
7925491 RGD
involved in positive regulation of hepatocyte proliferation IDA
IDA: Inferred from direct assay
16226713 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
7955315 RGD
involved in positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
9817766 RGD
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
IDA: Inferred from direct assay
7722643 RGD
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
17881084 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
21688311 RGD
involved in response to ciliary neurotrophic factor IEP
IEP: Inferred from expression pattern
16914133 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
9846168 RGD
involved in response to kainic acid IEP
IEP: Inferred from expression pattern
7477935 RGD
involved in response to nerve growth factor IEP
IEP: Inferred from expression pattern
16914133 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
9846168 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
7970205 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
8453763 RGD
involved in retinal rod cell differentiation IMP
IMP: Inferred from mutant phenotype
16914133 RGD
involved in rod bipolar cell differentiation IEP
IEP: Inferred from expression pattern
16914133 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
8453763 RGD
involved in thalamus development IEP
IEP: Inferred from expression pattern
10051750 RGD
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
9990431 RGD
located in cell surface IDA
IDA: Inferred from direct assay
8812110 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
12057922 RGD
located in neuromuscular junction IDA
IDA: Inferred from direct assay
8812110 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16226713 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
7955321 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
7955321 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pleiotrophin

  • HB-GAM

  • HBBM

  • HBGF-8

  • OSF-1

  • Pleiotrophin (Heparine binding factor, Hbnf, in the mouse)

  • heparin affine regulatory peptide

  • heparin binding factor

  • heparin-binding brain mitogen

  • heparin-binding growth factor 8

  • heparin-binding growth-associated molecule

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11407 PTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17103 Ptn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23547 Ptn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptn NCBI NCBI:5764