PTN - pleiotrophin Gene

Also Known as HARP; HBBM; HBNF; HBGF8; NEGF1; OSF-1; HB-GAM; HBGF-8; HBNF-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5764

About PTN

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:137,227,341-137,343,733 (from NCBI)

This gene has 3 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in brain (RPKM 83.5), prostate (RPKM 56.7) and 17 other tissues.

Summary

The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

PTN Products (3)

mRNA	Protein	Name
NM_001321386.2	NP_001308315.1	pleiotrophin isoform 1 precursor
NM_001321387.3	NP_001308316.1	pleiotrophin isoform 2 precursor
NM_002825.7	NP_002816.1	pleiotrophin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables carbohydrate binding	EXP EXP: Inferred from Experiment	26896299	GOA
enables chondroitin sulfate binding	IDA IDA: Inferred from direct assay	26896299	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	1733956	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	1733956	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	19141530	GOA
enables molecular function activator activity	IPI IPI: Inferred from physical interaction	21344482	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10706604	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	27445335	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	19141530	GOA
involved in ossification involved in bone remodeling	IDA IDA: Inferred from direct assay	19442624	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	1733956	GOA
involved in positive regulation of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	27445335	GOA
involved in positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	30667096	GOA
involved in receptor clustering	IDA IDA: Inferred from direct assay	27445335	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	1733956	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTN Protein Structure

PTN_MK_N

PTN_MK_C

0
100
168 a.a.

Protein Preferred Names	Protein Names
pleiotrophin	heparin affin regulatory protein

PTN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTN	P21246	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71907	Pleiotrophin Protein, Human	P21246 (G33-D168)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700145AF	Animal-Free Pleiotrophin Protein, Human (His)	P21246 (G33-D168)	≥ 95%, as determined by reducing SDS-PAGE.

PTN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82028	PTN Antibody (YA1773)	WB, IP	Human, Rat
HY-P82028A	PTN Antibody (YA1773)(PBS only)	WB, IP	Human, Rat

Related Diseases

Diseases	Alias
Nasal Cavity Olfactory Neuroblastoma	Olfactory Neuroblastoma Of The Nasal Cavity
Benign Meningioma	Meningioma, Benign
Common Peroneal Nerve Lesion	Lesion Of Lateral Popliteal Nerve Fibular Neuropathy
Glioma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Peyronie'S Disease	Induratio Penis Plastica Peyronie Disease Peyronies Disease Peyronie'S Fibromatosis Penile Induration Balanitis Xerotica Obliterans
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Brown-Sequard Syndrome	Brown-Squard Syndrome Hemicord Syndrome Hemiparaplegic Syndrome Hemispinal Cord Syndrome Brown-Séquard Syndrome
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11407	PTN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17103	Ptn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23547	Ptn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTN	VGNC	VGNC:45160
Mus musculus	PTN	MGD	MGI:97804
Felis catus	PTN	VGNC	VGNC:80664
Macaca mulatta	PTN	VGNC	VGNC:76594
Rattus norvegicus	PTN	RGD	RGD:3444
Bos taurus	PTN	VGNC	VGNC:33521
Others	PTN	NCBI