P2rx6 - purinergic receptor P2X 6 Gene

Also Known as P2x6; P2rxl1; Rnap2x6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25041

Summary

Enables extracellularly ATP-gated cation channel activity. Predicted to be involved in cation transmembrane transport; cell surface receptor signaling pathway; and response to ATP. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic specialization membrane. Orthologous to human P2RX6 (purinergic receptor P2X 6). [provided by Alliance of Genome Resources, Apr 2022]

P2rx6 Products (1)

mRNA Protein Name
NM_012721.2 NP_036853.2 P2X purinoceptor 6

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: Inferred from direct assay
8786426 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
24815693 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
17449665 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
11160443 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11160443 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11160443 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
11160443 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
11160443 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

P2X purinoceptor 6

  • ATP receptor

  • P2X6 receptor

  • P2XM

  • purinergic receptor P2X, ligand-gated ion channel, 6

  • purinergic receptor P2X-like 1 orphan receptor

  • purinergic receptor P2X6

P2rx6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
P2rx6 P51579 P2rx2 Rattus norvegicus P49653
IF
24815693
Intra
P2rx6 P51579 P2rx2 Rattus norvegicus P49653
Anti Tag CoIP
24815693
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09910 P2RX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx6 NCBI NCBI:9127