P2rx2 - purinergic receptor P2X 2 Gene

Also Known as P2X2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114115

About P2rx2

Primary_assembly 12: 46,339,549-46,342,891 forward strand.mRatBN7.2:CM026985.1

This gene has 3 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in Testes (RPKM 23.9), Uterus (RPKM 1.3) and 7 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and transition metal ion binding activity. Involved in several processes, including neuronal action potential; regulation of presynaptic cytosolic calcium ion concentration; and response to ischemia. Located in several cellular components, including dendritic spine; postsynaptic density; and presynaptic membrane. Is integral component of membrane. Part of receptor complex. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Apr 2022]

P2rx2 Products (2)

mRNA Protein Name
NM_053656.3 NP_446108.2 P2X purinoceptor 2
NM_053656.3 NP_446108.2 P2X purinoceptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
16190872 RGD
enables cadmium ion binding IDA
IDA: Inferred from direct assay
16190872 RGD
enables cobalt ion binding IDA
IDA: Inferred from direct assay
16190872 RGD
enables copper ion binding IDA
IDA: Inferred from direct assay
16190872 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: Inferred from direct assay
16190872 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
15317863 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
15313628 RGD
enables ligand-gated monoatomic ion channel activity IDA
IDA: Inferred from direct assay
7542879 RGD
enables mercury ion binding IDA
IDA: Inferred from direct assay
16190872 RGD
enables nickel cation binding IDA
IDA: Inferred from direct assay
16190872 RGD
enables phosphatidylinositol binding IMP
IMP: Inferred from mutant phenotype
16857707 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16330549 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15313628 RGD
enables purinergic nucleotide receptor activity IDA
IDA: Inferred from direct assay
16388598 RGD
enables suramin binding IDA
IDA: Inferred from direct assay
16388598 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
16190872 RGD
Biological Process GO Annotation Evidence References Source
involved in neuronal action potential IDA
IDA: Inferred from direct assay
16190872 RGD
involved in neuronal action potential IMP
IMP: Inferred from mutant phenotype
15317863 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration EXP
EXP: Inferred from Experiment
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IEP
IEP: Inferred from expression pattern
16000618 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IEP
IEP: Inferred from expression pattern
16000618 RGD
involved in response to ischemia IMP
IMP: Inferred from mutant phenotype
12849743 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
16388598 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
16330549 RGD
located in cell surface IDA
IDA: Inferred from direct assay
18616429 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
11160443 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
16000618 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11160443 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10974431 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
11160443 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
15313628 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
11160443 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
16000618 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
10974431 RGD
part of receptor complex IDA
IDA: Inferred from direct assay
15313628 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
10974431 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx2 Protein Structure

P2X

P2X: TIGR00863 (13 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 497 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 2

  • ATP receptor

  • purinergic receptor P2X, ligand-gated ion channel, 2

P2rx2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
P2rx2 P49653 P2rx6 Rattus norvegicus P51579
IF
24815693
Intra
P2rx2 P49653 P2rx4 Rattus norvegicus P51577
IF
24815693
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09900 P2RX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09901 P2rx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09902 P2rx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx2 NCBI NCBI:22953