P2rx4 - purinergic receptor P2X 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29659

About P2rx4

Primary_assembly 12: 33,844,396-33,862,253 reverse strand.mRatBN7.2:CM026985.1

This gene has 4 transcripts (splice variants), 211 orthologues, 6 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 179.), Kidney (RPKM 171.7) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; ligand-gated cation channel activity; and transition metal ion binding activity. Involved in several processes, including cellular response to zinc ion; neuronal action potential; and positive regulation of microglial cell migration. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Is integral component of plasma membrane. Biomarker of congestive heart failure. Orthologous to human P2RX4 (purinergic receptor P2X 4). [provided by Alliance of Genome Resources, Apr 2022]

P2rx4 Products (1)

mRNA Protein Name
NM_031594.2 NP_113782.2 P2X purinoceptor 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
12819199 RGD
enables ATP-gated ion channel activity IDA
IDA: Inferred from direct assay
24817123 RGD
enables copper ion binding IDA
IDA: Inferred from direct assay
12819199 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: Inferred from direct assay
8551329 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
15313628 RGD
enables ligand-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
17299767 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
24815693 RGD
enables purinergic nucleotide receptor activity IDA
IDA: Inferred from direct assay
12819199 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
17785580 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
12819199 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to pain IMP
IMP: Inferred from mutant phenotype
12917686 RGD
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
8551329 RGD
involved in cellular response to ATP IDA
IDA: Inferred from direct assay
8551329 RGD
involved in cellular response to zinc ion IDA
IDA: Inferred from direct assay
8551329 RGD
involved in inorganic cation transmembrane transport IDA
IDA: Inferred from direct assay
16282518 RGD
involved in neuronal action potential IDA
IDA: Inferred from direct assay
12819199 RGD
involved in positive regulation of microglial cell migration IMP
IMP: Inferred from mutant phenotype
17299767 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
17299767 RGD
involved in regulation of chemotaxis IMP
IMP: Inferred from mutant phenotype
17299767 RGD
NOT involved in regulation of ruffle assembly IMP
IMP: Inferred from mutant phenotype
17299767 RGD
involved in regulation of sodium ion transport IDA
IDA: Inferred from direct assay
17785580 RGD
involved in response to axon injury IMP
IMP: Inferred from mutant phenotype
12917686 RGD
involved in response to ischemia IMP
IMP: Inferred from mutant phenotype
12849743 RGD
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
12917686 RGD
involved in sensory perception of touch IMP
IMP: Inferred from mutant phenotype
12917686 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15476696 RGD
located in cell body IDA
IDA: Inferred from direct assay
12849743 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15476696 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
11160443 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11160443 RGD
located in lysosomal membrane IDA
IDA: Inferred from direct assay
24817123 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11160443 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
11160443 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
17785580 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
8551329 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
11160443 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
15476696 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx4 Protein Structure

P2X_receptor

P2X_receptor: pfam00864 (12 - 360)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 4

  • ATP receptor

  • P2X4

  • purinergic receptor P2X, ligand-gated ion channel 4

P2rx4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
P2rx4 P51577 P2rx2 Rattus norvegicus P49653
Anti Tag CoIP
24815693
Intra
P2rx4 P51577 P2rx4 Rattus norvegicus P51577
Comig Non-Denat Gel
19419241
Intra
P2rx4 P51577 P2rx6 Rattus norvegicus P51579
IF
24815693
Intra
P2rx4 P51577 P2rx6 Rattus norvegicus P51579
Anti Tag CoIP
24815693
Intra
P2rx4 P51577 P2rx4 Rattus norvegicus P51577
AFM
19419241
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09906 P2RX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09907 P2rx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09908 P2rx4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx4 NCBI NCBI:5025