Pld1 - phospholipase D1 Gene

Also Known as Plda; Pldb; Pld1a; Pld1b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25096

Summary

Enables Phospholipase D activity. Involved in phospholipid catabolic process; positive regulation of cell migration; and response to peptide hormone. Acts upstream of or within phosphatidic acid biosynthetic process. Located in Golgi cisterna; lamellipodium; and vesicle. Is active in synapse. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (Phospholipase D1). [provided by Alliance of Genome Resources, Apr 2022]

Pld1 Products (2)

mRNA Protein Name
NM_001399082.1 NP_001386011.1 phospholipase D1 isoform 1
NM_030992.3 NP_112254.2 phospholipase D1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phospholipase D activity IDA
IDA: Inferred from direct assay
12431982 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12431982 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within phosphatidic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
18519738 RGD
acts upstream of or within phospholipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
18519738 RGD
involved in phospholipid catabolic process IMP
IMP: Inferred from mutant phenotype
16459925 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
18344600 RGD
involved in response to peptide hormone IMP
IMP: Inferred from mutant phenotype
16459925 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi cisterna IDA
IDA: Inferred from direct assay
12429836 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
18344600 RGD
is active in synapse IDA
IDA: Inferred from direct assay
11752468 RGD
located in vesicle IDA
IDA: Inferred from direct assay
18344600 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipase D1

  • PLD 1

  • Phoshpolipase D gene 1 probably with two splicing variants A and B

  • choline phosphatase 1

  • phosphatidylcholine-hydrolyzing phospholipase D1

  • phospholipase D gene 1, probably with two splicing variants A and B

  • phospholipase D1, phosphatidylcholine-

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12807 FIPI Inhibitor 98.00% Unkown
HY-101293 VU0359595 Inhibitor 98.06% Unkown
HY-108612 VU0155069 Inhibitor 98.55% Unkown
HY-119093 Halopemide 99.65% Unkown
HY-155342 A3373 Inhibitor 99.57% Unkown
HY-108616 VU 0364739 hydrochloride Inhibitor / Unkown
HY-RS11140 PRKCSH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12807A FIPI hydrochloride Inhibitor / Unkown
HY-108612A VU0155069 hydrochloride Inhibitor / Unkown
HY-124305 ML395 / Unkown
HY-155343 A4333 Inhibitor / Unkown
HY-RS10670 PLD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19629 Pld1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26124 Pld1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pld1 NCBI NCBI:5337