Pld2 - phospholipase D2 Gene

Also Known as Pldc

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25097

Summary

Enables Phospholipase D activity and protein kinase C binding activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase signaling; regulation of vesicle-mediated transport; and response to hydrogen peroxide. Located in several cellular components, including caveola; lamellipodium; and sarcolemma. Biomarker of congestive heart failure and visual epilepsy. Orthologous to human PLD2 (Phospholipase D2). [provided by Alliance of Genome Resources, Apr 2022]

Pld2 Products (1)

mRNA	Protein	Name
NM_033299.2	NP_150641.2	phospholipase D2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phospholipase D activity	IDA IDA: Inferred from direct assay	9111050	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11876650	RGD
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	16113073	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	18004999	RGD
involved in phospholipid catabolic process	IMP IMP: Inferred from mutant phenotype	16459925	RGD
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	15976455	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18344600	RGD
involved in positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	16861349	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	15705590	RGD
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	15470141	RGD
involved in response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	15705590	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	11095536	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	11923096	RGD
involved in response to peptide hormone	IMP IMP: Inferred from mutant phenotype	16459925	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	12429836	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	18344600	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	10801846	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phospholipase D2	PLD 2 PLD1C choline phosphatase 2 phosphatidylcholine-hydrolyzing phospholipase D2 phospholipase D gene 2 rPLD2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12807	FIPI	Inhibitor	98.00%	Unkown
HY-101293	VU0359595	Inhibitor	98.06%	Unkown
HY-121983	CAY10594		98.64%	Unkown
HY-150412	VU0364739	Inhibitor	99.16%	Unkown
HY-119093	Halopemide		99.65%	Unkown
HY-116165	ML-298	Inhibitor	96.94%	Unkown
HY-155342	A3373	Inhibitor	99.57%	Unkown
HY-114095	BML-280	Inhibitor	99.64%	Unkown
HY-108616	VU 0364739 hydrochloride	Inhibitor	/	Unkown
HY-RS19152	Pld2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-12807A	FIPI hydrochloride	Inhibitor	/	Unkown
HY-108612A	VU0155069 hydrochloride	Inhibitor	/	Unkown
HY-124305	ML395		/	Unkown
HY-155343	A4333	Inhibitor	/	Unkown
HY-RS10671	PLD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25641	Pld2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pld2	NCBI	NCBI:5338