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Avpr1a - arginine vasopressin receptor 1A Gene

Also Known as V1a; AVPR; V1aR

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25107

About Avpr1a

Primary_assembly 7: 58,114,284-58,122,215 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 264 orthologues, 16 paralogues and is associated with 13 phenotypes. Biased expression in Liver (RPKM 395.2), Kidney (RPKM 31.7) and 2 other tissues.

Summary

This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues. [provided by RefSeq, Jul 2008]

Avpr1a Products (1)

mRNA	Protein	Name
NM_053019.2	NP_444178.2	vasopressin V1a receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables V1A vasopressin receptor binding	IDA IDA: Inferred from direct assay	1560825	RGD
enables peptide hormone binding	IMP IMP: Inferred from mutant phenotype	12942143	RGD
enables vasopressin receptor activity	IDA IDA: Inferred from direct assay	19560475	RGD
enables vasopressin receptor activity	IMP IMP: Inferred from mutant phenotype	12942143	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	12088846	RGD
involved in cellular response to water deprivation	IEP IEP: Inferred from expression pattern	11796498	RGD
involved in grooming behavior	IMP IMP: Inferred from mutant phenotype	18640147	RGD
involved in maternal aggressive behavior	IMP IMP: Inferred from mutant phenotype	18640147	RGD
involved in maternal behavior	IMP IMP: Inferred from mutant phenotype	18640147	RGD
involved in myotube differentiation	IEP IEP: Inferred from expression pattern	18021262	RGD
involved in negative regulation of female receptivity	IMP IMP: Inferred from mutant phenotype	16488546	RGD
involved in negative regulation of transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	16304841	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	18339407	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	17395547	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17395547	RGD
involved in positive regulation of cellular pH reduction	IMP IMP: Inferred from mutant phenotype	17762181	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	12088846	RGD
involved in positive regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	17877638	RGD
involved in positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	18339407	RGD
involved in positive regulation of prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	17254553	RGD
involved in positive regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	17350115	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	17428891	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	15475662	RGD
involved in social behavior	IDA IDA: Inferred from direct assay	12887422	RGD
involved in social behavior	IEP IEP: Inferred from expression pattern	16154572	RGD
involved in sperm ejaculation	IMP IMP: Inferred from mutant phenotype	18552879	RGD
involved in telencephalon development	IEP IEP: Inferred from expression pattern	11021977	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Avpr1a Protein Structure

7tmA_V1aR

DUF1856

0
100
200
300
400
424 a.a.

Protein Preferred Names	Protein Names
vasopressin V1a receptor	antidiuretic hormone receptor 1a arginine vasopressin receptor V1a vascular/hepatic-type arginine vasopressin receptor

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0049A	Argipressin diacetate		/	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4990	Pro8-Oxytocin	Activator	99.68%	Unkown
HY-P4990A	Pro8-Oxytocin TFA	Activator	99.68%	Unkown
HY-RS01281	AVPR1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01282	Avpr1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01283	Avpr1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Avpr1a	NCBI	NCBI:552