Avpr2 - arginine vasopressin receptor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25108

About Avpr2

Primary_assembly X: 151,633,522-151,635,989 forward strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 233 orthologues, 16 paralogues and is associated with 20 phenotypes. Biased expression in Kidney (RPKM 45.6), Thymus (RPKM 4.9) and 7 other tissues.

Summary

Predicted to enable peptide binding activity and Vasopressin Receptor activity. Involved in several processes, including negative regulation of renal sodium excretion; negative regulation of urine volume; and positive regulation of systemic arterial blood pressure. Predicted to be located in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Used to study hypertension. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to human AVPR2 (arginine Vasopressin Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Avpr2 Products (1)

mRNA Protein Name
NM_019136.2 NP_062009.1 vasopressin V2 receptor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of urine volume IMP
IMP: Inferred from mutant phenotype
18057218 RGD
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
12072411 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18787031 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16352747 RGD
involved in positive regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
18957383 RGD
involved in telencephalon development IEP
IEP: Inferred from expression pattern
11021977 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Avpr2 Protein Structure

7tmA_V2R

7tmA_V2R: cd15388 (69 - 357)

7tmA_V2R

7tmA_V2R: cd15388 (70 - 96)

7tmA_V2R

7tmA_V2R: cd15388 (105 - 132)

7tmA_V2R

7tmA_V2R: cd15388 (143 - 173)

7tmA_V2R

7tmA_V2R: cd15388 (186 - 207)

7tmA_V2R

7tmA_V2R: cd15388 (233 - 262)

7tmA_V2R

7tmA_V2R: cd15388 (295 - 325)

7tmA_V2R

7tmA_V2R: cd15388 (335 - 357)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

vasopressin V2 receptor

  • AVPR V2

  • V2R

  • Vasopressin receptor V2

  • antidiuretic hormone receptor

  • renal-type arginine vasopressin receptor

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0049A Argipressin diacetate / Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01287 AVPR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01288 Avpr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01289 Avpr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Avpr2 NCBI NCBI:554