Pcsk2 - proprotein convertase subtilisin/kexin type 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25121

Summary

Enables serine-type endopeptidase activity. Involved in islet amyloid polypeptide processing. Located in dendrite and perikaryon. Colocalizes with secretory granule. Used to study chronic kidney disease. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk2 Products (1)

mRNA Protein Name
NM_012746.2 NP_036878.1 neuroendocrine convertase 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16286464 RGD
enables serine-type endopeptidase activity EXP
EXP: Inferred from Experiment
1429623 RGD
enables serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
15983213 RGD
Biological Process GO Annotation Evidence References Source
involved in islet amyloid polypeptide processing IMP
IMP: Inferred from mutant phenotype
15983213 RGD
involved in peptide hormone processing IMP
IMP: Inferred from mutant phenotype
16497799 RGD
involved in protein processing IMP
IMP: Inferred from mutant phenotype
16497799 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
17543468 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17543468 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17543468 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
7822759 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroendocrine convertase 2

  • KEX2-like endoprotease 2

  • NEC 2

  • PC2

  • prohormone convertase 2

  • proprotein convertase 2

Pcsk2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pcsk2 P28841 Scg5 Rattus norvegicus P27682
Anti Bait CoIP
16286464
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10172 PCSK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21016 Pcsk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27533 Pcsk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcsk2 NCBI NCBI:5126