Igf2r - insulin-like growth factor 2 receptor Gene

Also Known as Igfr2; IGF-IIR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25151

Summary

Enables several functions, including G-protein alpha-subunit binding activity; insulin-like growth factor II binding activity; and retinoic acid binding activity. Involved in several processes, including animal organ regeneration; response to retinoic acid; and response to tetrachloromethane. Located in several cellular components, including extracellular space; late endosome; and perinuclear region of cytoplasm. Part of clathrin coat. Colocalizes with trans-Golgi network. Used to study lung adenocarcinoma. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (Insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf2r Products (1)

mRNA Protein Name
NM_012756.2 NP_036888.2 cation-independent mannose-6-phosphate receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IDA
IDA: Inferred from direct assay
16407557 RGD
enables enzyme binding IDA
IDA: Inferred from direct assay
11247783 RGD
enables insulin-like growth factor II binding IDA
IDA: Inferred from direct assay
16407557 RGD
enables retinoic acid binding IDA
IDA: Inferred from direct assay
10470859 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19095737 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
12547403 RGD
involved in liver development IDA
IDA: Inferred from direct assay
12127995 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19095737 RGD
involved in post-embryonic development IEP
IEP: Inferred from expression pattern
18824840 RGD
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16825605 RGD
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
9811861 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
9632637 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
10993842 RGD
Cellular Component GO Annotation Evidence References Source
part of clathrin coat IDA
IDA: Inferred from direct assay
2971973 RGD
located in endosome IDA
IDA: Inferred from direct assay
15033478 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
10470859 RGD
located in late endosome IDA
IDA: Inferred from direct assay
19337031 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15033478 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
15033478 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cation-independent mannose-6-phosphate receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06622 IGF2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-E70730 INSR Recombinant Human Active Protein Kinase / Unkown
HY-RS17981 Igf2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24452 Igf2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igf2r NCBI NCBI:3482