Gata2 - GATA binding protein 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25159

Summary

Enables sequence-specific DNA binding activity. Involved in several processes, including cochlea development; neuron migration; and regulation of vesicle-mediated transport. Located in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gata2 Products (1)

mRNA Protein Name
NM_033442.1 NP_254277.1 endothelial transcription factor GATA-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12557015 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11093771 RGD
Biological Process GO Annotation Evidence References Source
involved in cochlea development IEP
IEP: Inferred from expression pattern
20006695 RGD
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
21430145 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
22390417 RGD
involved in positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
22390417 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
21430145 RGD
involved in positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
12933836 RGD
involved in positive regulation of phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
12933836 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11093771 RGD
involved in response to lipid IEP
IEP: Inferred from expression pattern
11880336 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelial transcription factor GATA-2

  • GATA-bindning protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05290 GATA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174676 Human GATA2 mRNA / Unkown
HY-RS20027 Gata2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26530 Gata2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gata2 NCBI NCBI:2624