Rxra - retinoid X receptor alpha Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25271

Summary

Enables protein domain specific binding activity and retinoic acid receptor binding activity. Contributes to double-stranded DNA binding activity. Involved in several processes, including cellular response to Insulin stimulus; response to retinoic acid; and response to vitamin. Located in axon and nucleus. Biomarker of alcoholic cardiomyopathy and prostate carcinoma in situ. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human RXRA (retinoid X receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Rxra Products (1)

mRNA Protein Name
NM_012805.3 NP_036937.2 retinoic acid receptor RXR-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to double-stranded DNA binding IDA
IDA: Inferred from direct assay
17483744 RGD
enables nuclear retinoic acid receptor binding IPI
IPI: Inferred from physical interaction
15234273 RGD
enables nuclear thyroid hormone receptor binding IPI
IPI: Inferred from physical interaction
10037764 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9199332 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
9742117 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15234273 RGD
Biological Process GO Annotation Evidence References Source
involved in axon regeneration IEP
IEP: Inferred from expression pattern
16782282 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
9555940 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
16135695 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
14729401 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
15964596 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16344269 RGD
involved in placenta development IEP
IEP: Inferred from expression pattern
16135695 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16344269 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12105223 RGD
involved in regulation of myelination IDA
IDA: Inferred from direct assay
20648638 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
19791468 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
17483744 RGD
involved in response to glucocorticoid IMP
IMP: Inferred from mutant phenotype
19008781 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
14986719 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17270546 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
9555940 RGD
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
15318950 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
16180333 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
12048211 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
16782282 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinoic acid receptor RXR-alpha

  • nuclear receptor subfamily 2 group B member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12361 RXRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182415 RX-RA-69 Inhibitor / Unkown
HY-160212 JP3000 Agonist / Unkown
HY-RS17966 Rxra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24437 Rxra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rxra NCBI NCBI:6256