Ms4a2 - membrane spanning 4-domains A2 Gene

Also Known as FCIGA; Ms4a1; Fcer1b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25316

Summary

Enables SH2 domain binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to IgE receptor activity. Involved in several processes, including activation of Phospholipase C activity; positive regulation of mast cell degranulation; and protein kinase C-activating G protein-coupled receptor signaling pathway. Located in endosome and membrane raft. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; and rhinitis. Orthologous to human MS4A2 (membrane spanning 4-domains A2). [provided by Alliance of Genome Resources, Apr 2022]

Ms4a2 Products (1)

mRNA Protein Name
NM_012845.1 NP_036977.1 high affinity immunoglobulin epsilon receptor subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH2 domain binding IDA
IDA: Inferred from direct assay
8910399 RGD
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
8910399 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16177098 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
16177098 RGD
involved in regulation of release of sequestered calcium ion into cytosol IGI
IGI: Inferred from genetic interaction
16177098 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
11101638 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high affinity immunoglobulin epsilon receptor subunit beta

  • IgE Fc receptor subunit beta

  • Membrane-spanning 4-domains, subfamily A, member 1

  • beta polypeptide)

  • fc epsilon receptor I beta-chain

  • fcERI

  • membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for

  • membrane-s

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08697 Ms4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08700 MS4A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18183 Ms4a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24657 Ms4a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ms4a2 NCBI NCBI:2206