MS4A2 - membrane spanning 4-domains A2 Gene

Also Known as APY; IGEL; IGER; ATOPY; FCERI; IGHER; FCER1B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2206

About MS4A2

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:60,088,259-60,098,467 (from NCBI)

This gene has 4 transcripts (splice variants), 358 orthologues, 16 paralogues and is associated with 1 phenotype. Biased expression in lung (RPKM 8.1), gall bladder (RPKM 5.4) and 13 other tissues.

Summary

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]

MS4A2 Products (2)

mRNA Protein Name
NM_000139.5 NP_000130.1 high affinity immunoglobulin epsilon receptor subunit beta isoform 1
NM_001256916.2 NP_001243845.1 high affinity immunoglobulin epsilon receptor subunit beta isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in immune response IMP
IMP: Inferred from mutant phenotype
7920628 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MS4A2 Protein Structure

CD20

CD20: CD20-like family (61 - 203)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

high affinity immunoglobulin epsilon receptor subunit beta

  • Fc fragment of IgE, high affinity I, receptor for

MS4A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MS4A2 Q01362 TMEM86A Homo sapiens Q8N2M4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ige Responsiveness, Atopic

  • ATOPY

  • Atopy, Susceptibility To

  • Ige, Elevated Level Of

  • IGER

  • Immunoglobulin E, Basic Level Of, In Serum

  • Ige, Level Of

  • Igel

  • Ige Response Underlying Allergic Asthma And Rhinitis

  • Atopic Hypersensitivity

  • Immediate Hypersensitivity
Allergic Asthma

  • Atopic Asthma

  • Extrinsic Asthma

  • Extrinsic Asthma With Acute Exacerbation

  • Extrinsic Asthma With Status Asthmaticus

  • Asthma Allergic

  • Atopic Asthma, Susceptibility To

  • Ige-Mediated Allergic Asthma

  • Allergen-Induced Asthma

  • Allergic Asthma Without Stated Status Asthmaticus

  • Predominantly Allergic Asthma Without Stated Status Asthmaticus

  • Predominantly Allergic Asthma

  • Allergic Asthma Nos

  • Catarrh With Asthma

  • Allergic Bronchitis Nos

  • Extrinsic Allergic Asthma

  • Predominantly Allergic Asthma With Stated Status Asthmaticus
Childhood-Onset Asthma

  • Childhood Asthma

  • Asthma Childhood
Allergic Rhinitis

  • Hay Fever

  • Allergic Rhinitis, Susceptibility To

  • ALRH

  • Atopic Rhinitis

  • Seasonal Allergic Rhinitis

  • Non-Seasonal Allergic Rhinitis

  • Perenial Allergic Rhinitis

  • Pollenosis

  • Rhinitis Allergic Seasonal

  • Rhinitis, Allergic, Perennial

  • Allergic Rhinitis, Cause Unspecified

  • Pollinosis

  • Pollen Allergy

  • Allergy Nos Due To Pollen

  • Summer Catarrh

  • Other Seasonal Allergic Rhinitis
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Food Allergy

  • Food Hypersensitivity

  • Food Allergies

  • Allergy Food

  • Food Allergen-Induced Hypersensitivity
Type 1 Diabetes Mellitus 4

  • Diabetes Mellitus, Insulin-Dependent, 4

  • Iddm4

  • Insulin-Dependent Diabetes Mellitus 4

  • T1D4

  • Insulin-Dependent Diabetes Mellitus-4
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Fanconi Anemia, Complementation Group C

  • Fanconi Anemia Complementation Group C

  • FANCC

  • Facc

  • Fac

  • Fa3

  • Fanconi Pancytopenia Type 3

  • Fanconi Pancytopenia, Type 3

  • Faces Syndrome

  • Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

  • Friedman-Goodman Syndrome

  • Abnormality Of The Face
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08697 Ms4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08700 MS4A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18183 Ms4a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24657 Ms4a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MS4A2 RGD RGD:2598
Mus musculus MS4A2 MGD MGI:95495
Felis catus MS4A2 VGNC VGNC:108366
Bos taurus MS4A2 VGNC VGNC:31685
Macaca mulatta MS4A2 VGNC VGNC:74929
Canis familiaris MS4A2 VGNC VGNC:43432
Others MS4A2 NCBI