Npr3 - natriuretic peptide receptor 3 Gene

Also Known as NPRC; ANP-CR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25339

Summary

Enables identical protein binding activity; peptide hormone binding activity; and peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of Adenylate Cyclase activity; and positive regulation of nitric-oxide synthase activity. Located in membrane. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Npr3 Products (1)

mRNA Protein Name
NM_012868.1 NP_037000.1 atrial natriuretic peptide receptor 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled peptide receptor activity IDA
IDA: Inferred from direct assay
9843699 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
8702617 RGD
enables natriuretic peptide receptor activity IDA
IDA: Inferred from direct assay
9843699 RGD
enables natriuretic peptide receptor activity IMP
IMP: Inferred from mutant phenotype
7911802 RGD
enables peptide hormone binding IDA
IDA: Inferred from direct assay
8702617 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12676657 RGD
involved in negative regulation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
8702617 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
21457229 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15044621 RGD
involved in positive regulation of nitric-oxide synthase activity IDA
IDA: Inferred from direct assay
9843699 RGD
involved in positive regulation of pancreatic juice secretion IMP
IMP: Inferred from mutant phenotype
12829435 RGD
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
15337698 RGD
involved in vasodilation IMP
IMP: Inferred from mutant phenotype
17391657 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

atrial natriuretic peptide receptor 3

  • ANP-C

  • ANPR-C

  • ANPRC

  • Atrial natriuretic peptide clearence receptor 3

  • NPR-C

  • atrial natriuretic peptide C-type receptor

  • atrial natriuretic peptide clearance receptor

  • atrial natriuretic peptide receptor type C

  • natriuretic peptide receptor C/guanylate c

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1419 AP 811 Antagonist 99.64% Unkown
HY-P1419A AP 811 acetate Antagonist / Unkown
HY-RS09499 NPR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09501 NPRL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19149 Npr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25640 Npr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npr3 NCBI NCBI:4883