NPR3 - natriuretic peptide receptor 3 Gene

Also Known as NPRC; ANP-C; ANPRC; BOMOS; NPR-C; ANPR-C; GUCY2B; C5orf23

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4883

About NPR3

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:32,690,872-32,791,720 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 35.4), fat (RPKM 14.2) and 8 other tissues.

Summary

This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

NPR3 Products (6)

mRNA	Protein	Name
NM_000908.4	NP_000899.1	atrial natriuretic peptide receptor 3 isoform 2 precursor
NM_001204375.2	NP_001191304.1	atrial natriuretic peptide receptor 3 isoform 1 precursor
NM_001204376.2	NP_001191305.1	atrial natriuretic peptide receptor 3 isoform 3
NM_001363652.2	NP_001350581.1	atrial natriuretic peptide receptor 3 isoform 4
NM_001364458.2	NP_001351387.1	atrial natriuretic peptide receptor 3 isoform 5
NM_001364460.2	NP_001351389.1	atrial natriuretic peptide receptor 3 isoform 6

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chloride ion binding	IDA IDA: Inferred from direct assay	16870210	GOA
enables hormone binding	IPI IPI: Inferred from physical interaction	16870210	GOA
enables natriuretic peptide receptor activity	IDA IDA: Inferred from direct assay	1660465	GOA
enables peptide binding	IPI IPI: Inferred from physical interaction	16870210	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	1660465	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16870210	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16870210	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	16870210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPR3 Protein Structure

ANF_receptor

0
100
200
300
400
500
541 a.a.

Protein Preferred Names	Protein Names
atrial natriuretic peptide receptor 3	atrial natriuretic peptide clearance receptor

Recombinant NPR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71122	NPR3 Protein, Human (HEK293, Fc)	P17342-1 (T24-E481)	≥ 90%, as determined by reducing SDS-PAGE.

NPR3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81796	NPR3 Antibody (YA1541)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Boudin-Mortier Syndrome	BOMOS Tall Stature And Long Digits With Extra Epiphyses
Ischemic Colitis	Colitis, Ischemic Irreversible Ischaemic Colitis
Anismus
Acromesomelic Dysplasia	Acromesomelic Dwarfism Dysplasia, Acromesomelic Acromesomelic Dysplasia Hunter-Thompson Type
Functional Diarrhea	Functional Diarrhoea
Acromesomelic Dysplasia 1	Acromesomelic Dysplasia, Maroteaux Type Amdm Acromesomelic Dysplasia 1, Maroteaux Type AMD1 St. Helena Dysplasia Acromesomelic Dysplasia-1 Acromesomelic Dysplasia Maroteaux Type Acromesomelic Dwarfism Maroteux Type Dysplasia, Acromesomelic, Type 1, Maroteaux Acromesomelic Dysplasia Hunter-Thompson Type
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Secretory Diarrhea
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Volvulus Of Midgut	Volvulus Intestinal Volvulus Intestinal Malrotation, Familial Familial Intestinal Malrotation Twist Of Intestine, Bowel, Or Colon
Constipation
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1419	AP 811	Antagonist	99.64%	Unkown
HY-P1419A	AP 811 acetate	Antagonist	/	Unkown
HY-RS09499	NPR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09501	NPRL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19149	Npr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25640	Npr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NPR3	MGD	MGI:97373
Rattus norvegicus	NPR3	RGD	RGD:3196
Canis familiaris	NPR3	VGNC	VGNC:58320
Macaca mulatta	NPR3	VGNC	VGNC:75390
Felis catus	NPR3	VGNC	VGNC:68535
Others	NPR3	NCBI