Oxtr - oxytocin receptor Gene

Also Known as OTR; OT-R; OTR1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25342

About Oxtr

Primary_assembly 4: 145,599,561-145,614,674 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 265 orthologues, 16 paralogues and is associated with 25 phenotypes. Biased expression in Adrenal (RPKM 17.2), Uterus (RPKM 11.7) and 7 other tissues.

Summary

Enables Oxytocin Receptor activity and peptide hormone binding activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of synaptic transmission; and regulation of secretion. Located in adherens junction; apical plasma membrane; and microvillus. Used to study gastric ulcer. Biomarker of hypertension. Orthologous to human OXTR (Oxytocin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Oxtr Products (1)

mRNA Protein Name
NM_012871.4 NP_037003.2 oxytocin receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
25539504 RGD
enables oxytocin receptor activity IDA
IDA: Inferred from direct assay
15821089 RGD
enables peptide hormone binding IDA
IDA: Inferred from direct assay
15821089 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9176188 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
10497238 RGD
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9575824 RGD
involved in digestive tract development IEP
IEP: Inferred from expression pattern
19003903 RGD
involved in eating behavior IMP
IMP: Inferred from mutant phenotype
15380376 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
12867731 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
16832906 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
15316117 RGD
involved in maternal behavior IMP
IMP: Inferred from mutant phenotype
18513132 RGD
involved in maternal process involved in parturition IEP
IEP: Inferred from expression pattern
18936075 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
18304743 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
10497238 RGD
involved in positive regulation of norepinephrine secretion IMP
IMP: Inferred from mutant phenotype
14656297 RGD
involved in positive regulation of penile erection IMP
IMP: Inferred from mutant phenotype
18469843 RGD
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
16488155 RGD
involved in positive regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
11069593 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
18510735 RGD
involved in positive regulation of uterine smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
19164477 RGD
involved in response to amphetamine IMP
IMP: Inferred from mutant phenotype
17383105 RGD
involved in response to anoxia IMP
IMP: Inferred from mutant phenotype
18655887 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
16677710 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
10994633 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19258489 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11264328 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
12700188 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
10856882 RGD
involved in response to steroid hormone IMP
IMP: Inferred from mutant phenotype
12588901 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12834913 RGD
involved in social behavior IMP
IMP: Inferred from mutant phenotype
17383105 RGD
involved in sperm ejaculation IMP
IMP: Inferred from mutant phenotype
18469843 RGD
involved in suckling behavior IMP
IMP: Inferred from mutant phenotype
19106214 RGD
involved in telencephalon development IEP
IEP: Inferred from expression pattern
11021977 RGD
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
19003903 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11456414 RGD
located in microvillus IDA
IDA: Inferred from direct assay
11456414 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Oxtr Protein Structure

7tmA_OT_R

7tmA_OT_R: cd15387 (39 - 338)

7tmA_OT_R

7tmA_OT_R: cd15387 (40 - 66)

7tmA_OT_R

7tmA_OT_R: cd15387 (73 - 100)

7tmA_OT_R

7tmA_OT_R: cd15387 (111 - 141)

7tmA_OT_R

7tmA_OT_R: cd15387 (151 - 172)

7tmA_OT_R

7tmA_OT_R: cd15387 (196 - 225)

7tmA_OT_R

7tmA_OT_R: cd15387 (266 - 296)

7tmA_OT_R

7tmA_OT_R: cd15387 (306 - 331)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

oxytocin receptor

  • oxcytocin receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108678 TC OT 39 97.70% Unkown
HY-P4990 Pro8-Oxytocin Activator 99.68% Unkown
HY-P4990A Pro8-Oxytocin TFA Activator 99.68% Unkown
HY-P5017 (Val3,Pro8)-Oxytocin Agonist / Unkown
HY-RS09894 OXTR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09895 Oxtr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09896 Oxtr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180870 OXTR modulator-1 / Unkown
HY-180870A OXTR modulator-2 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oxtr NCBI NCBI:5021