Sftpd - surfactant protein D Gene

Also Known as SPD; SP-D

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25350

Summary

Enables identical protein binding activity; lipopolysaccharide binding activity; and monosaccharide binding activity. Involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Located in extracellular space; multivesicular body; and rough endoplasmic reticulum. Biomarker of Coronavirus infectious disease; asthma; Bacterial pneumonia; lung disease; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D). [provided by Alliance of Genome Resources, Apr 2022]

Sftpd Products (1)

mRNA Protein Name
NM_012878.3 NP_037010.1 pulmonary surfactant-associated protein D precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
19017984 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
19007302 RGD
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
18092821 RGD
enables monosaccharide binding IDA
IDA: Inferred from direct assay
18092821 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of T cell proliferation IDA
IDA: Inferred from direct assay
9794387 RGD
involved in negative regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
9794387 RGD
involved in negative regulation of phagocytosis IDA
IDA: Inferred from direct assay
12654779 RGD
involved in opsonization IDA
IDA: Inferred from direct assay
19017984 RGD
involved in positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
15591410 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
8292379 RGD
involved in response to growth factor IEP
IEP: Inferred from expression pattern
11076805 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
11472975 RGD
involved in surfactant homeostasis IDA
IDA: Inferred from direct assay
9201966 RGD
involved in surfactant homeostasis IMP
IMP: Inferred from mutant phenotype
10666121 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11472975 RGD
located in multivesicular body IDA
IDA: Inferred from direct assay
16187065 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pulmonary surfactant-associated protein D

  • CP4

  • PSP-D

  • lung surfactant protein D

  • pulmonary surfactant protein D

  • surfactant associated protein D

  • surfactant, pulmonary-associated protein D

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12784 SFTPD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17774 Sftpd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24241 Sftpd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sftpd NCBI NCBI:6441
Mus musculus Sftpd NCBI NCBI:20390
Macaca mulatta Sftpd NCBI NCBI:678657