IFI6 - interferon alpha inducible protein 6 Gene

Also Known as 6-16; G1P3; FAM14C; IFI616; IFI-6-16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2537

About IFI6

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,666,064-27,672,192 (from NCBI)

This gene has 4 transcripts (splice variants), 89 orthologues and 3 paralogues. Broad expression in placenta (RPKM 111.6), salivary gland (RPKM 40.6) and 21 other tissues.

Summary

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of Apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]

IFI6 Products (3)

mRNA	Protein	Name
NM_002038.4	NP_002029.3	interferon alpha-inducible protein 6 isoform a precursor
NM_022872.3	NP_075010.1	interferon alpha-inducible protein 6 isoform b precursor
NM_022873.3	NP_075011.1	interferon alpha-inducible protein 6 isoform c precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15685448	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	27673746	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	26244642	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	25757571	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	25757571	GOA
involved in intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	26244642	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17823654	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	15685448	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	15685448	GOA
involved in negative regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	15685448	GOA
involved in reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	29899394	GOA
involved in regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25757571	GOA
involved in release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	15685448	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	29899394	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	17823654	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15685448	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFI6 Protein Structure

Ifi-6-16

0
100
130 a.a.

Protein Preferred Names	Protein Names
interferon alpha-inducible protein 6	interferon, alpha-inducible protein clone IFI-6-16

Related Diseases

Diseases	Alias
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06558	IFI6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown