Aqp2 - aquaporin 2 Gene

Also Known as AQP-2; aquaporin-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25386

Summary

Enables PDZ domain binding activity; actin binding activity; and water transmembrane transporter activity. Involved in several processes, including actin filament depolymerization; cellular response to water deprivation; and response to glucagon. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and trans-Golgi network. Part of protein-containing complex. Used to study diabetes insipidus. Biomarker of hypertension and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus. Orthologous to human AQP2 (Aquaporin 2). [provided by Alliance of Genome Resources, Apr 2022]

Aqp2 Products (1)

mRNA Protein Name
NM_012909.3 NP_037041.3 aquaporin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
15196935 RGD
enables actin binding IDA
IDA: Inferred from direct assay
15336526 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17636261 RGD
enables water transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
9321919 RGD
Biological Process GO Annotation Evidence References Source
involved in actin filament depolymerization IDA
IDA: Inferred from direct assay
18678705 RGD
involved in cell volume homeostasis IMP
IMP: Inferred from mutant phenotype
18094031 RGD
involved in cellular response to water deprivation IDA
IDA: Inferred from direct assay
15196935 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
18293204 RGD
involved in hyperosmotic response IEP
IEP: Inferred from expression pattern
19138132 RGD
involved in positive regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
18094031 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
19138132 RGD
involved in response to glucagon IEP
IEP: Inferred from expression pattern
18829741 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
17376764 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18824919 RGD
involved in response to salt stress IEP
IEP: Inferred from expression pattern
12176047 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
15610244 RGD
involved in water transport IEP
IEP: Inferred from expression pattern
11518698 RGD
involved in water transport IMP
IMP: Inferred from mutant phenotype
9321919 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11518698 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15579502 RGD
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
18843259 RGD
located in early endosome IDA
IDA: Inferred from direct assay
18843259 RGD
located in exocytic vesicle IDA
IDA: Inferred from direct assay
15037626 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
9321919 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15196935 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
15905145 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aquaporin-2

  • ADH water channel

  • AQP-CD

  • WCH-CD

  • aquaporin 2 (collecting duct)

  • aquaporin-CD

  • collecting duct water channel protein

  • water channel protein for renal collecting duct

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2057 Steviol Inhibitor 99.85% Unkown
HY-W288951 FMP-API-1 Activator / Unkown
HY-E70797 Biotin-CaMK2δ CAMK2D Recombinant Human Active Protein Kinase / Unkown
HY-RS00874 AQP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17446 Aqp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18336 Aqp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24815 Aqp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aqp2 NCBI NCBI:359
Mus musculus Aqp2 NCBI NCBI:11827