Camk2a - calcium/calmodulin-dependent protein kinase II alpha Gene

Also Known as PKCCD; PK2CDD

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25400

About Camk2a

Primary_assembly 18: 54,378,784-54,438,994 forward strand.mRatBN7.2:CM026991.1

This gene has 4 transcripts (splice variants), 167 orthologues, 21 paralogues and is associated with 20 phenotypes. Biased expression in Brain (RPKM 681.4) and Muscle (RPKM 138.5).

Summary

Enables GTPase activating protein binding activity and calmodulin-dependent protein kinase activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; protein phosphorylation; and regulation of protein localization to cell periphery. Located in several cellular components, including dendrite cytoplasm; glutamatergic postsynaptic density; and neuronal cell body. Is active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Orthologous to human CAMK2A (calcium/Calmodulin dependent protein kinase II alpha). [provided by Alliance of Genome Resources, Apr 2022]

Camk2a Products (1)

mRNA Protein Name
NM_012920.1 NP_037052.1 calcium/calmodulin-dependent protein kinase type II subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activating protein binding IPI
IPI: Inferred from physical interaction
12951199 RGD
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: Inferred from direct assay
11972023 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12933808 RGD
Biological Process GO Annotation Evidence References Source
involved in ionotropic glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
12223541 RGD
involved in neurotransmitter receptor transport to plasma membrane IMP
IMP: Inferred from mutant phenotype
34233182 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
12951199 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
16095822 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12401560 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
12202034 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
12202034 RGD
involved in regulation of protein localization to plasma membrane IGI
IGI: Inferred from genetic interaction
19188609 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
12176168 RGD
located in dendrite IDA
IDA: Inferred from direct assay
7820660 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
1419001 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12202034 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
12202034 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
7820660 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
17957478 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
20878786 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
17957478 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Camk2a Protein Structure

STKc_CaMKII

STKc_CaMKII: cd14086 (10 - 301)

CaMKII_AD

CaMKII_AD: pfam08332 (356 - 483)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 489 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type II subunit alpha

  • Ca2+/calmodulin-dependent protein kinase II alpha

  • alpha CaM kinase II

  • caM kinase II subunit alpha

  • caM-kinase II alpha chain

  • caMK-II subunit alpha

  • calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha

  • calcium/calmodulin-dependent protein kinase II alpha subunit

  • calcium/calmodulin-dependent protein kinase type II alpha chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137506 XST-14 99.26% Unkown
HY-N1989 Bacoside A / Unkown
HY-RS01854 CAMK2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01855 Camk2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01856 Camk2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Camk2a NCBI NCBI:815