2. Gene
  3. Camk2a - calcium/calmodulin-dependent protein kinase II alpha Gene

Camk2a - calcium/calmodulin-dependent protein kinase II alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PKCCD; PK2CDD

Gene ID: 25400 | Gene type: protein coding

About Camk2a

Primary_assembly 18: 54,378,784-54,438,994 forward strand.mRatBN7.2:CM026991.1

This gene has 4 transcripts (splice variants), 167 orthologues, 21 paralogues and is associated with 20 phenotypes. Biased expression in Brain (RPKM 681.4) and Muscle (RPKM 138.5).

Summary

Enables GTPase activating protein binding activity and calmodulin-dependent protein kinase activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; protein phosphorylation; and regulation of protein localization to cell periphery. Located in several cellular components, including dendrite cytoplasm; glutamatergic postsynaptic density; and neuronal cell body. Is active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Orthologous to human CAMK2A (calcium/Calmodulin dependent protein kinase II alpha). [provided by Alliance of Genome Resources, Apr 2022]

Camk2a Products(1)

mRNA Protein Name
NM_012920.1 NP_037052.1 calcium/calmodulin-dependent protein kinase type II subunit alpha

Camk2a Protein Structure

STKc_CaMKII

STKc_CaMKII: cd14086 (10 - 301)

CaMKII_AD

CaMKII_AD: pfam08332 (356 - 483)

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  • 489 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type II subunit alpha

Ca2+/calmodulin-dependent protein kinase II alpha

alpha CaM kinase II

caM kinase II subunit alpha

caM-kinase II alpha chain

caMK-II subunit alpha

calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha

calcium/calmodulin-dependent protein kinase II alpha subunit

calcium/calmodulin-dependent protein kinase type II alpha chain

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137506 XST-14 99.69% Unkown
HY-RS01854 CAMK2A Human Pre-designed siRNA Set A / Unkown
HY-RS01855 Camk2a Mouse Pre-designed siRNA Set A / Unkown
HY-RS01856 Camk2a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Camk2a NCBI NCBI:815