2. Gene
  3. CAMK2A - calcium/calmodulin dependent protein kinase II alpha Gene

CAMK2A - calcium/calmodulin dependent protein kinase II alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAMKA; MRD53; MRT63; CaMKIIalpha; CaMKIINalpha

Gene ID: 815 | Gene type: protein coding

About CAMK2A

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,219,491-150,290,130 (from NCBI)

This gene has 23 transcripts (splice variants), 167 orthologues, 22 paralogues and is associated with 4 phenotypes. Restricted expression toward brain (RPKM 112.2).

Summary

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]

CAMK2A Products(5)

mRNA Protein Name
NM_015981.4 NP_057065.2 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1
NM_001369025.2 NP_001355954.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3
NM_171825.3 NP_741960.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001363990.1 NP_001350919.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001363989.1 NP_001350918.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1

CAMK2A Protein Structure

Pkinase

Pkinase: Protein kinase domain (13 - 271)

CaMKII_AD

CaMKII_AD: Calcium/calmodulin dependent protein kinase II association domain (346 - 473)

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  • 478 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type II subunit alpha

CaM kinase II alpha subunit

CaM-kinase II alpha chain

CaMK-II alpha subunit

caM kinase II subunit alpha

caMK-II subunit alpha

calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha

calcium/calmodulin-dependent protein kinase II alpha-B subunit

calcium/calmodulin-dependent protein kinase type II alpha chain

Recombinant CAMK2A Proteins

Cat. No. Product Name Accession Purity
HY-P76761 CaMKII alpha/CAMK2A Protein, Human (sf9, GST) Q9UQM7-1 (M1-H478) ≥95%

Related Diseases

Diseases Alias
Rett Syndrome

Atypical Rett Syndrome

RTT

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Atypical

Rett Syndrome, Preserved Speech Variant

Rett'S Disorder

Rett Syndrome Variant

Rett Disorder

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Intellectual Developmental Disorder, Autosomal Recessive 63

MRT63

Mental Retardation, Autosomal Recessive 63
Intellectual Developmental Disorder, Autosomal Dominant 53

MRD53

Mental Retardation, Autosomal Dominant 53

Autosomal Dominant Intellectual Developmental Disorder 53

Autosomal Dominant Mental Retardation 53

Mental Retardation, Autosomal Dominant, Type 53
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autosomal Dominant Non-Syndromic Intellectual Disability
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137506 XST-14 99.69% Unkown
HY-RS01854 CAMK2A Human Pre-designed siRNA Set A / Unkown
HY-RS01855 Camk2a Mouse Pre-designed siRNA Set A / Unkown
HY-RS01856 Camk2a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CAMK2A VGNC VGNC:38680
Macaca mulatta CAMK2A VGNC VGNC:70523
Bos taurus CAMK2A VGNC VGNC:26721
Rattus norvegicus CAMK2A RGD RGD:2261
Felis catus CAMK2A VGNC VGNC:60331
Mus musculus CAMK2A MGD MGI:88256
Others CAMK2A NCBI