CAMK2A - calcium/calmodulin dependent protein kinase II alpha Gene

Also Known as CAMKA; MRD53; MRT63; CaMKIIalpha; CaMKIINalpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 815

About CAMK2A

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,219,491-150,290,130 (from NCBI)

This gene has 23 transcripts (splice variants), 167 orthologues, 22 paralogues and is associated with 4 phenotypes. Restricted expression toward brain (RPKM 112.2).

Summary

The product of this gene belongs to the serine/threonine protein kinases family, and to the CA(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]

CAMK2A Products (5)

mRNA	Protein	Name
NM_015981.4	NP_057065.2	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1
NM_001369025.2	NP_001355954.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3
NM_171825.3	NP_741960.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001363990.1	NP_001350919.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001363989.1	NP_001350918.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	11972023	GOA
enables calmodulin binding	IPI IPI: Inferred from physical interaction	20668654	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20668654	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	17052756	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17052756	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20668654	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	28130356	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in angiotensin-activated signaling pathway	IDA IDA: Inferred from direct assay	20584908	GOA
involved in cellular response to interferon-beta	IDA IDA: Inferred from direct assay	35568036	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	11972023	GOA
involved in dendritic spine development	IMP IMP: Inferred from mutant phenotype	28130356	GOA
involved in peptidyl-threonine autophosphorylation	IMP IMP: Inferred from mutant phenotype	28130356	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	17052756	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	11972023	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17052756	GOA
involved in regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	29100089	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of calcium- and calmodulin-dependent protein kinase complex	IDA IDA: Inferred from direct assay	20668654	GOA
located in dendritic spine	IDA IDA: Inferred from direct assay	28130356	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK2A Protein Structure

Pkinase

CaMKII_AD

0
100
200
300
400
478 a.a.

Protein Preferred Names	Protein Names
calcium/calmodulin-dependent protein kinase type II subunit alpha	CaM kinase II alpha subunit CaM-kinase II alpha chain CaMK-II alpha subunit caM kinase II subunit alpha caMK-II subunit alpha calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha calcium/calmodulin-dependent protein kinase II alpha-B subunit calcium/calmodulin-dependent protein kinase type II alpha chain

CAMK2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CAMK2A	Q9UQM7	CAMK2B	Homo sapiens	Q13554	Anti Bait CoIP	17353931
Intra	CAMK2A	Q9UQM7	CAMK2B	Homo sapiens	Q13554	Pull Down	32707033
Intra	CAMK2A	Q9UQM7	CAMK2B	Homo sapiens	Q13554	Anti Tag CoIP	33961781
Intra	CAMK2A	Q9UQM7	CAMK2B	Homo sapiens	Q13554	TAP	27173435
Intra	CAMK2A	Q9UQM7	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Pull Down	32707033
Intra	CAMK2A	Q9UQM7	CAMK2G	Homo sapiens	Q13555	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	CAMK2G	Homo sapiens	Q13555	Anti Tag CoIP	25852190
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Anti Tag CoIP	33961781
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Anti Bait CoIP	17353931
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Solution Sedimentation	20668654
Intra	CAMK2A	Q9UQM7	CAMK2G	Homo sapiens	Q13555	Anti Tag CoIP	33961781
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Anti Tag CoIP	25852190
Intra	CAMK2A	Q9UQM7	CAMK2G	Homo sapiens	Q13555	Pull Down	32707033
Intra	CAMK2A	Q9UQM7	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	CAMK2A	Q9UQM7	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	CAMK2A	Q9UQM7	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	CAMK2A	Q9UQM7	GRIN2B	Homo sapiens	Q13224	Pull Down	19453375
Intra	CAMK2A	Q9UQM7	GRIN2B	Homo sapiens	Q13224	Competition Binding	19453375
Intra	CAMK2A	Q9UQM7	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	CAMK2A	Q9UQM7	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CAMK2A	Q9UQM7	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	33961781
Intra	CAMK2A	Q9UQM7	MRPL11	Homo sapiens	Q9Y3B7	Validated Y2H	32296183
Intra	CAMK2A	Q9UQM7	PNP	Homo sapiens	P00491	Y2H Pooling	32814053
Intra	CAMK2A	Q9UQM7	PNP	Homo sapiens	P00491	Validated Y2H	32814053
Intra	CAMK2A	Q9UQM7	PNP	Homo sapiens	P00491	Y2H Array	32814053
Intra	CAMK2A	Q9UQM7	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	CAMK2A	Q9UQM7	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	CAMK2A	Q9UQM7	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAMK2A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76761	CaMKII alpha/CAMK2A Protein, Human (Active, sf9, GST)	Q9UQM7-1 (M1-H478)	≥ 85%, as determined by reducing SDS-PAGE.

CAMK2A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80445	CaMKII alpha Antibody (YA569)	WB, IP, FC, IHC-P	Human, Mouse, Rat
HY-P810536	Phospho-CaMKII (Thr286) Antibody (YA9806)	WB, IHC-P, IP, ICC/IF, IF-Tissue	Human, Mouse, Rat
HY-P84930	CaMKII Antibody (YA4627)	WB, IHC-P, IHC-F, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat, Monkey, Pig
HY-P86365	CaMKII alpha Antibody (YA6057)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Rett Syndrome	Atypical Rett Syndrome RTT Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Atypical Rett Syndrome, Preserved Speech Variant Rett'S Disorder Rett Syndrome Variant Rett Disorder Cerebroatrophic Hyperammonemia Rett Like Syndrome Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Schizophrenia 12	Sczd12 Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Intellectual Developmental Disorder, Autosomal Recessive 63	MRT63 Mental Retardation, Autosomal Recessive 63
Intellectual Developmental Disorder, Autosomal Dominant 53	MRD53 Mental Retardation, Autosomal Dominant 53 Autosomal Dominant Intellectual Developmental Disorder 53 Autosomal Dominant Mental Retardation 53 Mental Retardation, Autosomal Dominant, Type 53
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Autosomal Dominant Non-Syndromic Intellectual Disability
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137506	XST-14		99.26%	Unkown
HY-N1989	Bacoside A		/	Unkown
HY-RS01854	CAMK2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01855	Camk2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01856	Camk2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CAMK2A	VGNC	VGNC:38680
Macaca mulatta	CAMK2A	VGNC	VGNC:70523
Bos taurus	CAMK2A	VGNC	VGNC:26721
Rattus norvegicus	CAMK2A	RGD	RGD:2261
Felis catus	CAMK2A	VGNC	VGNC:60331
Mus musculus	CAMK2A	MGD	MGI:88256
Others	CAMK2A	NCBI