Ctsc - cathepsin C Gene

Rattus norvegicus

Also known as CATC; DPPI; DPP-I

Gene ID: 25423 | Gene type: protein coding

About Ctsc

Primary_assembly 1: 142,028,392-142,060,387 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 233 orthologues, 27 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 64.8), Kidney (RPKM 269.7) and 7 other tissues.

Summary

Enables several functions, including chaperone binding activity; chloride ion binding activity; and identical protein binding activity. Involved in several processes, including aging; positive regulation of proteolysis involved in cellular protein catabolic process; and proteolysis. Located in Golgi apparatus; endoplasmic reticulum; and lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (Cathepsin C). [provided by Alliance of Genome Resources, Apr 2022]

Ctsc Products(1)

mRNA	Protein	Name
NM_017097.2	NP_058793.1	dipeptidyl peptidase 1 precursor

Ctsc Protein Structure

CathepsinC_exc

Pox_I6

Peptidase_C1A_CathepsinC

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

dipeptidyl peptidase 1

cathepsin J	dipeptidyl peptidase I
dipeptidyl transferase

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112318A	GSK-2793660	Inhibitor	99.66%	Phase 1
HY-112318	GSK-2793660 free base	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120709	GSK2793660 hydrochloride	Inhibitor	/	Unkown
HY-RS03325	CTSC Human Pre-designed siRNA Set A		/	Unkown
HY-RS03326	Ctsc Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03327	Ctsc Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctsc	NCBI	NCBI:1075
Mus musculus	Ctsc	NCBI	NCBI:13032

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