Ctsc - cathepsin C Gene

Also Known as CATC; DPPI; DPP-I

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25423

About Ctsc

Primary_assembly 1: 142,028,392-142,060,387 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 233 orthologues, 27 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 64.8), Kidney (RPKM 269.7) and 7 other tissues.

Summary

Enables several functions, including chaperone binding activity; chloride ion binding activity; and identical protein binding activity. Involved in several processes, including aging; positive regulation of proteolysis involved in cellular protein catabolic process; and proteolysis. Located in Golgi apparatus; endoplasmic reticulum; and lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (Cathepsin C). [provided by Alliance of Genome Resources, Apr 2022]

Ctsc Products (2)

mRNA Protein Name
NM_017097.2 NP_058793.1 dipeptidyl peptidase 1 precursor
NM_017097.2 NP_058793.1 dipeptidyl peptidase 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chloride ion binding IDA
IDA: Inferred from direct assay
11602245 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
11602245 RGD
enables phosphatase binding IPI
IPI: Inferred from physical interaction
18307834 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
18307834 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of proteolysis involved in protein catabolic process IDA
IDA: Inferred from direct assay
18307834 RGD
Cellular Component GO Annotation Evidence References Source
located in lysosome IDA
IDA: Inferred from direct assay
18307834 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsc Protein Structure

CathepsinC_exc

CathepsinC_exc: pfam08773 (24 - 137)

Pox_I6

Pox_I6: cl28439 (167 - 203)

Peptidase_C1A_CathepsinC

Peptidase_C1A_CathepsinC: cd02621 (229 - 458)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 1

  • cathepsin J

  • dipeptidyl peptidase I

  • dipeptidyl transferase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-112318A GSK-2793660 Inhibitor 99.91% Phase 1
HY-112318 GSK-2793660 free base Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03325 CTSC Human Pre-designed siRNA Set A / Unkown
HY-168591 CTSC-IN-1 Inhibitor / Unkown
HY-RS03326 Ctsc Mouse Pre-designed siRNA Set A / Unkown
HY-RS03327 Ctsc Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsc NCBI NCBI:1075
Mus musculus Ctsc NCBI NCBI:13032