Ctse - cathepsin E Gene

Also Known as CEA; CEB; Ctsea

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25424

About Ctse

Primary_assembly 13: 43,092,128-43,114,502 forward strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 142 orthologues, 8 paralogues and is associated with 7 phenotypes. Biased expression in Spleen (RPKM 389.2), Thymus (RPKM 338.8) and 2 other tissues.

Summary

Enables aspartic-type endopeptidase activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II and protein autoprocessing. Located in endosome. Orthologous to human CTSE (Cathepsin E). [provided by Alliance of Genome Resources, Apr 2022]

Ctse Products (2)

mRNA Protein Name
NM_012938.2 NP_037070.2 cathepsin E isoform 1 precursor
NM_001401267.1 NP_001388196.1 cathepsin E isoform 2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase activity IDA
IDA: Inferred from direct assay
8157122 RGD
Biological Process GO Annotation Evidence References Source
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
8491674 RGD
involved in protein autoprocessing IMP
IMP: Inferred from mutant phenotype
16367762 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
9572291 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctse Protein Structure

A1_Propeptide

A1_Propeptide: pfam07966 (22 - 50)

pepsin_retropepsin_like

pepsin_retropepsin_like: cl11403 (79 - 394)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

cathepsin E

Recombinant Ctse Proteins

Cat. No. Product Name Accession Purity
HY-P74344 Cathepsin E Protein, Rat (HEK293, His) AAH62002 (V22-P398) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03331 CTSE Human Pre-designed siRNA Set A / Unkown
HY-RS03332 Ctse Mouse Pre-designed siRNA Set A / Unkown
HY-RS03333 Ctse Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctse NCBI NCBI:1510