CTSE - cathepsin E Gene

Also Known as CATE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1510

About CTSE

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,009,264-206,023,895 (from NCBI)

This gene has 9 transcripts (splice variants), 142 orthologues and 9 paralogues. Biased expression in stomach (RPKM 543.0) and duodenum (RPKM 112.5).

Summary

This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]

CTSE Products (5)

mRNA Protein Name
XM_011509245.2 XP_011507547.1 cathepsin E isoform X2
XM_011509244.2 XP_011507546.1 cathepsin E isoform X1
NM_148964.3 NP_683865.1 cathepsin E isoform b precursor
NM_001317331.2 NP_001304260.1 cathepsin E isoform c
NM_001910.4 NP_001901.1 cathepsin E isoform a preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase activity IDA
IDA: Inferred from direct assay
7789521 GOA
enables peptidase activity IDA
IDA: Inferred from direct assay
16997486 GOA
Biological Process GO Annotation Evidence References Source
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
8765029 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
16997486 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
7983070 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTSE Protein Structure

A1_Propeptide

A1_Propeptide: A1 Propeptide (21 - 49)

Asp

Asp: Eukaryotic aspartyl protease (77 - 394)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
Protein Preferred Names Protein Names

cathepsin E

  • erythrocyte membrane aspartic proteinase

  • slow-moving proteinase

Recombinant CTSE Proteins

Cat. No. Product Name Accession Purity
HY-P7750 Cathepsin E Protein, Human (HEK293, His) P14091 (S20-P396) ≥ 95%, as determined by reducing SDS-PAGE.

CTSE Antibodies

Cat. No. Product Name Application Reactivity
HY-P83658 CTSE Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Gastric Cancer

  • Stomach Cancer

  • Stomach Carcinoma

  • Gastric Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Tetanus

  • Lockjaw

  • Clostridial Tetanus

  • Infection Due To Clostridium Tetani

  • Lock-Jaw
Gastric Tubular Adenocarcinoma

  • Tubular Adenocarcinoma Of Stomach
Ceroid Lipofuscinosis, Neuronal, 10

  • Neuronal Ceroid Lipofuscinosis Due To Cathepsin D Deficiency

  • Neuronal Ceroid Lipofuscinosis 10

  • CLN10

  • Cathepsin D Deficiency

  • Congenital Neuronal Ceroid Lipofuscinosis

  • Neuronal Ceroid Lipofuscinosis Cathepsin D-Deficient

  • Cln10 Disease

  • Ceroid Lipofuscinosis, Neuronal, Cathepsin D-Deficient

  • Cln10 Disease, Adult

  • Cln10 Disease, Congenital

  • Cln10 Disease, Juvenile

  • Cln10 Disease, Late Infantile

  • Ceroid Lipofuscinosis Neuronal Cathepsin D-Deficient

  • Cathepsin D Deficient Neuronal Ceroid Lipofuscinosis

  • Congenital Ncl

  • Lipofuscinosis, Ceroid, Neuronal, Type 10

  • Neuronal Ceroid Lipofuscinosis, Congenital
Gastric Papillary Adenocarcinoma

  • Papillary Adenocarcinoma Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03331 CTSE Human Pre-designed siRNA Set A / Unkown
HY-RS03332 Ctse Mouse Pre-designed siRNA Set A / Unkown
HY-RS03333 Ctse Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CTSE VGNC VGNC:71554
Canis familiaris CTSE VGNC VGNC:39710
Mus musculus CTSE MGD MGI:107361
Rattus norvegicus CTSE RGD RGD:2446
Felis catus CTSE VGNC VGNC:61267
Others CTSE NCBI