Nedd4 - NEDD4 E3 ubiquitin protein ligase Gene

Also Known as Nedd4a

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25489

Summary

Enables protein C-terminus binding activity and ubiquitin-protein transferase activity. Involved in several processes, including regulation of postsynaptic neurotransmitter receptor internalization; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to denervation involved in regulation of muscle adaptation. Located in membrane raft and microvillus. Is active in glutamatergic synapse. Biomarker of muscular atrophy. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Nedd4 Products (1)

mRNA	Protein	Name
NM_012986.1	NP_037118.1	E3 ubiquitin-protein ligase NEDD4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8665844	RGD
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20159449	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in immune response	IEP IEP: Inferred from expression pattern	11248052	RGD
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	20159449	RGD
involved in regulation of dendrite morphogenesis	IDA IDA: Inferred from direct assay	20159449	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	21148011	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: Inferred from expression pattern	21148011	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	21148011	RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IDA IDA: Inferred from direct assay	21148011	RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IEP IEP: Inferred from expression pattern	21148011	RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	21148011	RGD
involved in regulation protein catabolic process at postsynapse	IDA IDA: Inferred from direct assay	21148011	RGD
involved in regulation protein catabolic process at postsynapse	IEP IEP: Inferred from expression pattern	21148011	RGD
involved in regulation protein catabolic process at postsynapse	IMP IMP: Inferred from mutant phenotype	21148011	RGD
involved in response to denervation involved in regulation of muscle adaptation	IEP IEP: Inferred from expression pattern	19125695	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21148011	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21148011	RGD
located in microvillus	IDA IDA: Inferred from direct assay	9227416	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase NEDD4	HECT-type E3 ubiquitin transferase NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase neural precursor cell expressed, developmentally down-regulated gene 4 neural precursor cell expressed, developmenta

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110204	Heclin	Inhibitor	98.00%	Unkown
HY-134417	NSC2805	Inhibitor	99.42%	Unkown
HY-162809	XMU-MP-9		99.12%	Unkown
HY-N10159	1-Benzyl-I3C	Inhibitor	99.68%	Unkown
HY-110174	NAB2	Degrader	99.69%	Unkown
HY-153178	HECT E3-IN-1	Inhibitor	99.44%	Unkown
HY-122046	Amb123203		98.87%	Unkown
HY-179570	XMU-MP-10	Inhibitor	98.10%	Unkown
HY-RS09180	NEDD4L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09179	NEDD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-124791	MMRi6		99.70%	Unkown
HY-RS17116	Nedd4l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17232	Nedd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23561	Nedd4l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23685	Nedd4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nedd4	NCBI	NCBI:4734